{{Rsnum
|rsid=1992660
|Gene=PTGER4
|Chromosome=5
|position=40414965
|Orientation=minus
|GMAF=0.4619
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 35.4 | 52.3 | 12.3
| HCB | 8.9 | 15.6 | 75.6
| JPT | 0.0 | 15.9 | 84.1
| YRI | 39.7 | 49.2 | 11.1
| ASW | 0.0 | 0.0 | 0.0
| CHB | 8.9 | 15.6 | 75.6
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs1992660]] is a SNP upstream of the [[PTGER4]] gene that was found in a genome-wide association study to be associated with [[Crohn's disease]].

In several European populations, the most common allele, [[rs1992660]](A), was associated with increased risk for [[Crohn's disease]]. Conversely, the odds ratio (pooled over several populations) for the minor allele, [[rs1992660]](G), was 0.72 (CI: 0.60-0.86, p=0.0005).{{PMID|17684544|OA=1
}}
{{GWAS Summary
|SNP=rs1992660
|PubMedID=17684544
|Condition=Irritable bowel syndrome
|Gene=PTGER4
|Risk Allele=
|pValue=4.00E-007
|OR=1.42
|95CI=1.24-1.67
|OA=1
}}

{{omim
|desc=INFLAMMATORY BOWEL DISEASE 18; IBD18
|id=612262
|rsnum=1992660
}}

{{PharmGKB
|RSID=rs1992660
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17684544; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Systematic association mapping identifies NELL1 as a novel IBD disease gene (Initial Sample Size: 393 cases, 399 controls; Replication Sample Size: 2,920 cases, 1,961 controls, 1,248 trios). This variant is associated with Irritable bowel syndrome.
|Drugs=
|Drug Classes=
|Diseases=Colonic Diseases, Functional
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356577
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1992660
|overall_frequency_n=71
|overall_frequency_d=126
|overall_frequency=0.563492
|n_genomes=38
|n_genomes_annotated=0
|n_haplomes=57
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}