{{Rsnum
|rsid=2010963
|Gene=VEGFA
|Chromosome=6
|position=43770613
|Orientation=plus
|GMAF=0.3434
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=VEGFA
}}{{PMID Auto
|PMID=19308252
|Title=Genetic variation in VEGF does not contribute significantly to the risk of congenital cardiovascular malformation
|OA=1
}}

{{PMID Auto
|PMID=19761764
|Title=Association between vascular endothelial growth factor gene polymorphisms and age-related macular degeneration in a Polish population
}}
{{PMID Auto
|PMID=19594543
|Title=Effect of vascular endothelial growth factor polymorphisms on survival in advanced-stage non-small-cell lung cancer
}}
{{PMID Auto
|PMID=19875757
|Title=Clinical relevance of vascular endothelial growth factor (VEGFA) and VEGF receptor (VEGFR2) gene polymorphism on the treatment outcome following imatinib therapy
}}

{{PharmGKB
|RSID=rs2010963
|Name_s=VEGFA:405G>C; VEGF-A 405 G/C
|Gene_s=VEGFA
|Feature=
|Evidence=PubMed ID:20125120
|Annotation=Risk or phenotype-associated allele: GC. Phenotype: Response was observed in 27% of the patients with the +405 GC genotype compared with 54% with GG+CC. This genotype was also associated with poor progression free survival (PFS). Study size: 72. Study population/ethnicity: Patients with metastatic colorectal neoplasms; Denmark. Significance metric(s): p = 0.02 (response); HR = 1.65, CI 0.98-2.77, p = 0.04. Type of association: PD; CO
|Drugs=capecitabine; oxaliplatin
|Drug Classes=
|Diseases=Colorectal Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA165282110
}}
{{PMID Auto
|PMID=20082870
|Title=A Single Nucleotide Polymorphism in the Vascular Endothelial Growth Factor Gene Is Associated with Recurrence of Hepatocellular Carcinoma after Transplantation
}}

{{PMID Auto
|PMID=20132989
|Title=Phenotype and Genotype Characteristics of Age-related Macular Degeneration in a Japanese Population
}}

{{PMID Auto
|PMID=20209496
|Title=Possible association between polymorphisms of human vascular endothelial growth factor a gene and susceptibility to glioma in a Chinese population
}}

{{PMID Auto
|PMID=20489684
|Title=Vascular Endothelial Growth Factor Polymorphisms and Extent of Coronary Atherosclerosis in Chinese Population With Advanced Coronary Artery Disease
}}
{{PMID Auto
|PMID=20210775
|Title=The role of vascular endothelial growth factor gene as the genetic marker of atherothrombotic disorders and in the gene therapy of coronary artery disease
}}
{{PMID Auto
|PMID=20678803
|Title=Complement Factor H and High-Temperature Requirement A-1 Genotypes and Treatment Response of Age-related Macular Degeneration
}}
{{PMID Auto
|PMID=20847577
|Title=Vascular Endothelial Growth Factor Gene Polymorphisms and Risk of Neovascular Age-Related Macular Degeneration in a Chinese Cohort
}}

{{PharmGKB
|RSID=rs2010963
|Name_s=VEGFA:C405G
|Gene_s=VEGFA
|Feature=
|Evidence=PubMed ID:18223238
|Annotation=Individual genotypes of this SNP were not associated with risk of non-small cell lung cancer (NSCLC); however, the combined CC + CG genotype was significantly associated with slightly higher risk of NSCLC.
|Drugs=
|Drug Classes=
|Diseases=Carcinoma, Non-Small-Cell Lung
|Curation Level=Curated
|PharmGKB Accession ID=PA164891513
}}

{{PMID Auto
|PMID=21316969
|Title=Polymorphisms of the vascular endothelial growth factor A gene and susceptibility to sporadic brain arteriovenous malformation in a Chinese population
}}

{{omim
|id=192240
|rsnum=2010963
|variant=0001
}}

{{PMID Auto
|PMID=19653005
|Title=The combined impact of metabolic gene polymorphisms on elite endurance athlete status and related phenotypes
}}

{{PMID Auto
|PMID=22015057
|Title=Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study
}}

{{PMID Auto
|PMID=22129133
|Title=VEGFA and VEGFR2 genetic polymorphisms and survival in patients with diffuse large B cell lymphoma
}}

{{PMID Auto
|PMID=22209952
|Title=Vascular endothelial growth factor (VEGF) +405 C/G polymorphism is associated with essential hypertension in a population from Tehran of Iran
}}

{{PMID Auto
|PMID=22258388
|Title=Association of NOS2 and potential effect of VEGF, IL6, CCL2 and IL1RN polymorphisms and haplotypes on susceptibility to GCA--a simultaneous study of 130 potentially functional SNPs in 14 candidate genes
}}

{{PMID Auto
|PMID=22162628
|Title=Polymorphisms in the vascular endothelial growth factor gene and the risk of diabetic retinopathy in Chinese patients with type 2 diabetes
|OA=1
}}

{{PMID Auto
|PMID=22521084
|Title=Role of Vascular Endothelial Growth Factor Polymorphisms in the Treatment Success in Patients with Wet Age-related Macular Degeneration.
}}

{{PMID Auto
|PMID=22818823
|Title=Association of VEGF-A genetic polymorphisms with cancer risk and survival in advanced-stage oral squamous cell carcinoma patients
}}

{{PMID|15338501}} Vascular endothelial growth factor gene polymorphisms in Behcet's disease.

{{PMID|16142870}} A functional variant of vascular endothelial growth factor is associated with severe ischemic complications in giant cell arteritis.

{{PMID|16216669}} Analysis of vascular endothelial growth factor (VEGF) functional variants in rheumatoid arthritis.

{{PMID|16395752}} Association between functional haplotypes of vascular endothelial growth factor and renal complications in Henoch-Schonlein purpura.

{{PMID|16613616|OA=1
}} Polymorphisms in the vascular endothelial growth factor gene and breast cancer in the Cancer Prevention Study II cohort.

{{PMID|16645995}} Vascular endothelial growth factor gene haplotypes in Kawasaki disease.

{{PMID|16685110}} Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population.

{{PMID|17204151|OA=1
}} VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis.

{{PMID|17319747|OA=1
}} Large-scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer risk.

{{PMID|17601350|OA=1
}} A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

{{PMID|17625508}} VEGF C-634G polymorphism is associated with protection from isolated ventricular septal defect: case-control and TDT studies.

{{PMID|17917691|OA=1
}} Genetic markers and biomarkers for age-related macular degeneration.

{{PMID|17983459}} Vascular endothelial growth factor (VEGF) gene (VEGFA) polymorphism can predict the prognosis in acute myeloid leukaemia patients.

{{PMID|18281657}} VEGF polymorphisms and survival in early-stage non-small-cell lung cancer.

{{PMID|18378209}} Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration.

{{PMID|18650217}} Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis.

{{PMID|18780893|OA=1
}} Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk.

{{PMID|18805939|OA=1
}} Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.

{{PMID|19026761|OA=1
}} Molecular pathology of age-related macular degeneration.

{{PMID|19041064}} Vascular endothelial growth factor gene polymorphisms may predict the risk of acute graft-versus-host disease following allogeneic transplantation: preventive effect of vascular endothelial growth factor gene on acute graft-versus-host disease.

{{PMID|19089753}} Variation in the vascular endothelial growth factor gene, carotid intima-media thickness and the risk of acute myocardial infarction.

{{PMID|19438866|OA=1
}} Polymorphisms in genes involved in DNA repair, cell growth, oxidative stress and inflammatory response, and melanoma risk.

{{PMID|19566948|OA=1
}} Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer.

{{PMID|19584152|OA=1
}} Vascular endothelial growth factor polymorphisms and esophageal cancer prognosis.

{{PMID|19587357|OA=1
}} A systematic meta-analysis of genetic association studies for diabetic retinopathy.

{{PMID|19603096|OA=1
}} An analysis of growth, differentiation and apoptosis genes with risk of renal cancer.

{{PMID|19628492}} Polymorphism of the manganese superoxide dismutase gene but not of vascular endothelial growth factor gene is a risk factor for diabetic retinopathy.

{{PMID|19755511|OA=1
}} The role of vascular endothelial growth factor SNPs as predictive and prognostic markers for major solid tumors.

{{PMID|19787077|OA=1
}} Association of vascular endothelial growth factor polymorphisms with asthma in Tunisian children.

{{PMID|19835575|OA=1
}} The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.

{{PMID|20140301}} VEGFA polymorphisms and cardiovascular anomalies in 22q11 microdeletion syndrome: a case-control and family-based study.

{{PMID|20389299|OA=1
}} Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.

{{PMID|20444917}} Association of vascular endothelial growth factor polymorphisms with nonproliferative and proliferative diabetic retinopathy.

{{PMID|20621071}} Functional vascular endothelial growth factor gene polymorphisms and diabetes: effect on coronary collaterals in patients with significant coronary artery disease.

{{PMID|20706635|OA=1
}} Human genetics of diabetic retinopathy: current perspectives.

{{PMID|20832104}} Vascular endothelial growth factor gene polymorphisms and ovarian cancer survival.

{{PMID|21245770}} Vascular endothelial growth factor gene polymorphisms and rheumatoid arthritis.

{{PMID|21347390|OA=1
}} Genetics of VEGF serum variation in human isolated populations of cilento: importance of VEGF polymorphisms.

{{PMID|21362767}} Interaction between smoking and polymorphism in the promoter region of the VEGFA gene is associated with ischemic heart disease and myocardial infarction in rheumatoid arthritis.

{{PMID|21388351}} Vascular endothelial growth factor A and cardiovascular disease in rheumatoid arthritis patients.

{{PMID|21982816}} Contribution of VEGF polymorphisms to variation in VEGF serum levels in a healthy population.

{{PMID|22139971}} Vascular endothelial growth factor (VEGF) gene polymorphisms may influence the efficacy of thalidomide in multiple myeloma.

{{PMID|22307787}} Pooled-analysis of the associations between three polymorphisms in the VEGF gene and age-related macular degeneration.

{{PMID|22320189|OA=1
}} Polymorphisms of the vascular endothelial growth factor gene and severe radiation pneumonitis in non-small cell lung cancer patients treated with definitive radiotherapy.

{{PMID|22427559}} Vascular endothelial growth factor gene polymorphisms and choroidal neovascularization in highly myopic eyes.

{{PMID|22429695}} Polymorphism in the vascular endothelial growth factor A (VEGFA) gene is associated with serum VEGF-A level and disease activity in rheumatoid arthritis: differential effect of cigarette smoking.

{{PMID Auto
|PMID=23073296
|Title=VEGF Polymorphisms are not associated with an Increased Risk of Developing Renal Cell Carcinoma in Spanish population
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2010963
|overall_frequency_n=58
|overall_frequency_d=92
|overall_frequency=0.630435
|n_genomes=33
|n_genomes_annotated=0
|n_haplomes=50
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23211130
|Title=Polymorphisms in the vascular endothelial growth factor gene associated with recurrent spontaneous miscarriage
}}

{{PMID Auto
|PMID=22776467
|Title=Age at onset of rheumatoid arthritis: association with polymorphisms in the vascular endothelial growth factor A(VEGFA) gene and an intergenic locus between matrix metalloproteinase (MMP) 1 and 3 genes
}}

{{PMID Auto
|PMID=23490417
|Title=Single nucleotide polymorphism in the FLT4 gene is associated with atopic dermatitis in Koreans
}}

{{PMID Auto
|PMID=23511629
|Title=VEGF and VEGFR polymorphisms affect clinical outcome in advanced renal cell carcinoma patients receiving first-line sunitinib
|OA=1
}}

{{PMID Auto
|PMID=23673188
|Title=Vascular Endothelial Growth Factor gene (VEGFA) polymorphisms may serve as a prognostic factors for recurrent depressive disorder development
}}

{{PMID Auto
|PMID=23794399
|Title=VEGFA, FLT1, KDR and colorectal cancer: Assessment of disease risk, tumor molecular phenotype, and survival
}}

{{PMID Auto
|PMID=23848209
|Title=Vascular endothelial growth factor A (VEGFA) polymorphisms in Chinese patients with rheumatoid arthritis
}}

{{PMID Auto
|PMID=23880405
|Title=Methionine sulfoxide reductase A rs10903323 G/A polymorphism is associated with increased risk of coronary artery disease in a Chinese population
}}

{{PMID Auto
|PMID=24039754
|Title=The impact of polymorphic variations in the 5p15, 6p12, 6p21 and 15q25 Loci on the risk and prognosis of portuguese patients with non-small cell lung cancer
|OA=1
}}

{{PMID Auto
|PMID=24321896
|Title=Effect of Genetic Polymorphisms of Vascular Endothelial Growth Factor on Left Ventricular Hypertrophy in Patients With Systemic Hypertension
}}

{{PMID Auto
|PMID=24353087
|Title=Assessment of the associations between three VEGF polymorphisms and risk of prostate cancer
}}

{{PMID Auto
|PMID=22865486
|Title=Interaction among nitric oxide (NO)-related genes in migraine susceptibility.
}}

{{PMID Auto
|PMID=22915033
|Title=The C allele of -634G/C polymorphism in the VEGFA gene is associated with increased VEGFA gene expression in human retinal tissue.
}}

{{PMID Auto
|PMID=22925497
|Title=The relation of vascular endothelial growth factor (VEGF) gene polymorphisms on VEGF levels and the risk of vasoocclusive crisis in sickle cell disease.
}}

{{PMID Auto
|PMID=23007311
|Title=VEGF genetic polymorphisms affect the responsiveness to sildenafil in clinical and postoperative erectile dysfunction.
}}

{{PMID Auto
|PMID=23061744
|Title=Association of the vascular endothelial growth factor gene polymorphisms (-460C/T, +405G/C and +936T/C) with endometriosis: a meta-analysis.
}}

{{PMID Auto
|PMID=23064377
|Title=Influence of vascular endothelial growth factor single nucleotide polymorphisms on non-small cell lung cancer tumor angiogenesis.
|OA=1
}}

{{PMID Auto
|PMID=23353010
|Title=VEGF -634G>C polymorphism and diabetic retinopathy risk: a meta-analysis.
}}

{{PMID Auto
|PMID=23545315
|Title=Further evidence for the contribution of the vascular endothelial growth factor gene in coronary artery disease susceptibility.
}}

{{PMID Auto
|PMID=23553563
|Title=VEGFA SNPs and transcriptional factor binding sites associated with high altitude sickness in Han and Tibetan Chinese at the Qinghai-Tibetan Plateau.
}}

{{PMID Auto
|PMID=23644986
|Title=Genetic polymorphisms of vascular endothelial growth factor and risk for retinopathy of prematurity in South of Iran.
}}

{{PMID Auto
|PMID=24868559
|Title=The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies
}}

{{PMID Auto
|PMID=24652518
|Title=VEGFA and VEGFR2 gene polymorphisms and response to anti-vascular endothelial growth factor therapy: comparison of age-related macular degeneration treatments trials (CATT)
}}

{{PMID Auto
|PMID=25148899
|Title=Investigating the association of vascular endothelial growth factor polymorphisms with breast cancer: a Moroccan case-control study
}}

{{PMID Auto
|PMID=25239121
|Title=Variants in angiogenesis-related genes and the risk of clear cell renal cell carcinoma
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}