{{Rsnum
|rsid=2016520
|Gene=PPARD
|Chromosome=6
|position=35411001
|Orientation=plus
|GMAF=0.2314
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PPARD
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 61.9 | 32.7 | 5.3
| HCB | 54.7 | 38.0 | 7.3
| JPT | 58.4 | 38.1 | 3.5
| YRI | 44.9 | 42.9 | 12.2
| ASW | 47.4 | 45.6 | 7.0
| CHB | 54.7 | 38.0 | 7.3
| CHD | 43.1 | 43.1 | 13.8
| GIH | 64.4 | 32.7 | 3.0
| LWK | 49.1 | 34.5 | 16.4
| MEX | 81.0 | 19.0 | 0.0
| MKK | 52.9 | 34.8 | 12.3
| TSI | 59.8 | 34.3 | 5.9
| HapMapRevision=28
}}

Associated with baseline [[cholesterol]] levels in a study of 9,000+ individuals in Washington County, Maryland.{{PMID|18288282|OA=1
}}

{{ neighbor
| rsid = 2267668
| distance = 856
}}

{{PMID Auto
|PMID=19383774
|Title=A single nucleotide polymorphism on exon-4 of the gene encoding PPAR{delta} is associated with reduced [[height]] in adults and children
}}

{{PharmGKB
|RSID=rs2016520
|Name_s=PPARD:rs2016520 A>G; NM_006238.3:c.-87C>T
|Gene_s=PPARD
|Feature=5' UTR
|Evidence=PubMed ID:20038957
|Annotation=Risk or phenotype-associated allele: G Phenotype: The PPAR delta SNP rs2016520 A>G was associated with positive clincial response (partial or complete response) to treatment. Study size: 47 Study population/ethnicity: Patients diagnosed with castration-resistant prostate cancer enrolled in a randomized phase II clinical trial comparing docetaxel to docetaxel with thalidomide. Significance metric(s): p = 0.0056 Type of association: PD; CO
|Drugs=docetaxel; thalidomide
|Drug Classes=
|Diseases=Prostatic Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA165111524
}}

{{PMID Auto
|PMID=19653005
|Title=The combined impact of metabolic gene polymorphisms on elite [[endurance]] athlete status and related phenotypes
}}

{{PMID Auto
|PMID=22192471
|Title=The peroxisome proliferator-activated receptor delta +294T &gt; C polymorphism and alcohol consumption on serum lipid levels
|OA=1
}}

{{PMID Auto
|PMID=16979821
|Title=PPARD haplotype influences cholesterol metabolism but is no risk factor of Alzheimer's disease.
}}

{{PMID Auto
|PMID=18375961
|Title=Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China.
|OA=1
}}

{{PMID Auto
|PMID=18657264
|Title=Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity.
|OA=1
}}

{{PMID Auto
|PMID=18676870
|Title=Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.
|OA=1
}}

{{PMID Auto
|PMID=19666693
|Title=Is there an interaction between PPARD T294C and PPARGC1A Gly482Ser polymorphisms and human endurance performance?
}}

{{PMID Auto
|PMID=20200337
|Title=Peroxisome proliferator-activated receptor-delta genotype influences metabolic phenotype and may influence lipid response to statin therapy in humans: a genetics of diabetes audit and research Tayside study.
}}

{{PMID Auto
|PMID=20808897
|Title=Disease-associated mutations that alter the RNA structural ensemble.
|OA=1
}}

{{PMID Auto
|PMID=20811626
|Title=Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
|OA=1
}}

{{PMID Auto
|PMID=21487230
|Title=Effects of peroxisome proliferator-activated receptors, dietary fat intakes and gene-diet interactions on peak particle diameters of low-density lipoproteins.
}}

{{PMID Auto
|PMID=22968028
|Title=[Association of both peroxisome proliferator-activated receptor, gene-gene interactions and the body mass index]
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2016520
|overall_frequency_n=87
|overall_frequency_d=128
|overall_frequency=0.679688
|n_genomes=45
|n_genomes_annotated=0
|n_haplomes=71
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23545576
|Title=Association of peroxisome proliferator-activated receptor α/δ/γ with obesity, and gene-gene interaction, in the Chinese Han population
|OA=1
}}

{{PMID Auto
|PMID=23906684
|Title=Genetic associations with coronary heart disease: Meta-analyses of 12 candidate genetic variants
}}

{{PMID Auto
|PMID=23937834
|Title=[Effects related to gene-gene interactions of peroxisome proliferator-activated receptor on essential hypertension]
}}

{{PMID Auto
|PMID=23363867
|Title=[Gene-gene interactions among the peroxisome proliferator-activated receptor polymorphisms for hypertriglyceridemia]
}}

{{PMID Auto
|PMID=23355348
|Title=Interactions of several single nucleotide polymorphisms and high body mass index on serum lipid traits.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}