{{Rsnum
|rsid=2020917
|Gene=TXNRD2
|Chromosome=22
|position=19941361
|Orientation=plus
|GMAF=0.2282
|Gene_s=COMT,TXNRD2
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 43.4 | 46.9 | 9.7
| HCB | 45.3 | 47.4 | 7.3
| JPT | 45.1 | 46.0 | 8.8
| YRI | 86.4 | 12.9 | 0.7
| ASW | 89.5 | 10.5 | 0.0
| CHB | 45.3 | 47.4 | 7.3
| CHD | 54.1 | 36.7 | 9.2
| GIH | 58.4 | 35.6 | 5.9
| LWK | 81.8 | 16.4 | 1.8
| MEX | 70.7 | 24.1 | 5.2
| MKK | 70.5 | 26.3 | 3.2
| TSI | 50.0 | 43.1 | 6.9
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs2020917
|Name_s=
|Gene_s=COMT, TXNRD2
|Feature=Intron, Intron
|Evidence=PubMed ID:18632656
|Annotation=This promoter variant is associated with breast cancer risk reduction in two of three case control studies. Functional studies showed that it altered nuclear protein binding patterns and was associated with the up-regulation of transcription, possibly resulting in increased COMT activity.
|Drugs=
|Drug Classes=
|Diseases=Breast Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA162168062
}}

{{PMID Auto
|PMID=16848906
|Title=Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans.
|OA=1
}}

{{PMID Auto
|PMID=18436194
|Title=Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.
|OA=1
}}

{{PMID Auto
|PMID=18574484
|Title=The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase.
|OA=1
}}

{{PMID Auto
|PMID=19673036
|Title=Association of tagging single nucleotide polymorphisms on 8 candidate genes in dopaminergic pathway with schizophrenia in Croatian population.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2020917
|overall_frequency_n=23
|overall_frequency_d=124
|overall_frequency=0.185484
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=16
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22705295
|Title=Association of MB-COMT polymorphisms with schizophrenia-susceptibility and symptom severity in an African cohort.
}}

{{PMID Auto
|PMID=23351565
|Title=Potential role of membrane-bound COMT gene polymorphisms in female depression vulnerability.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}