{{Rsnum
|rsid=20417
|Gene=PTGS2
|Chromosome=1
|position=186681189
|Orientation=minus
|GMAF=0.1731
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=PTGS2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 6.3 | 27.0 | 66.7
| HCB | 0.0 | 13.3 | 86.7
| JPT | 0.0 | 11.4 | 88.6
| YRI | 17.7 | 46.8 | 35.5
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 13.3 | 86.7
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs20417]], also known as -765G>C, is a SNP in the Prostaglandin endoperoxidase synthase 2 [[PTGS2]] gene.

{{PMID|12920574}} In a group of Pima Indians, individuals with the variant [[PTGS2]] [[rs20417]] CC genotype had a 30% higher Type 2 [[diabetes]] prevalence compared with subjects with the GG genotype

{{PMID|19488068}} rs20417 was not found to be associated with prostate cancer in a large case-control study (n(cases)=1608, n(controls)=3058), nor in a meta-analysis of 3 other studies.

{{ neighbor
| rsid = 689465
| distance = 525
}}

{{ neighbor
| rsid = 20415
| distance = 366
}}

{{PMID Auto
|PMID=19455278
|Title=Functional polymorphisms of the cyclooxygenase (PTGS2) gene and risk for gallbladder cancer in a North Indian population
}}
{{PMID Auto
|PMID=19468846
|Title=Effect of COX2 -765G&gt;C and c.3618A&gt;G polymorphisms on the risk and survival of sporadic colorectal cancer
}}
{{PMID Auto
|PMID=19488068
|Title=PTGS2-899G&gt;C and prostate cancer risk: a population-based nested case-control study (ProtecT) and a systematic review with meta-analysis
}}

{{PMID Auto
|PMID=19046748
|Title=Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke
|OA=1
}}

{{PharmGKB
|RSID=rs20417
|Name_s=COX-2 G-765C
|Gene_s=PTGS2
|Feature=
|Evidence=PubMed ID:17350020; PubMed ID:17495879
|Annotation=Risk or phenotype-associated allele: C. Phenotype: COX-2 -765C is predictive of incident stroke in African Americans but not Whites. Study size: 2362. Study population/ethnicity: Atherosclerosis Risk in Communities Study, ARIC study; African Americans; Whites; USA. Significance metric(s): p = 0.03 Type of association: CO.
|Drugs=
|Drug Classes=
|Diseases=Stroke
|Curation Level=Curated
|PharmGKB Accession ID=PA165291724
}}
{{PMID Auto
|PMID=20033767
|Title=Current evidence on the relationship between polymorphisms in the COX-2 gene and breast cancer risk: a meta-analysis
}}

{{PMID Auto
|PMID=20177132
|Title=COX-2 is Associated with Periodontitis in Europeans
}}

{{PMID Auto
|PMID=20299798
|Title=Functional rs20417 SNP (-765G&gt;C) of Cyclooxygenase-2 Gene Does Not Predict the Risk of Recurrence of Ischemic Events in Coronary Patients: Results of a 7-Year Prospective Study
}}
{{PMID Auto
|PMID=20378913
|Title=The (-765 G-&gt;C) promoter variant of the COX-2/PTGS2 gene is associated with a lower risk for end-stage hip and knee osteoarthritis
}}
{{PMID Auto
|PMID=20472470
|Title=Impact of COX-2 rs5275 and rs20417 and GPIIIa rs5918 Polymorphisms on 90-Day Ischemic Stroke Functional Outcome: A Novel Finding
}}
{{PMID Auto
|PMID=20686383
|Title=Cyclooxygenase-2 gene polymorphisms and risk of cervical cancer in a North Indian population
}}

{{PharmGKB
|RSID=rs20417
|Name_s=PTGS2:-765G>C
|Gene_s=PTGS2
|Feature=
|Evidence=PubMed ID:15138244; PubMed ID:15150618; PubMed ID:15767339; PubMed ID:16678543; PubMed ID:17495879
|Annotation=Decreased anti-inflammatory and analgesic effects after minor dental surgery in patients with -765G>C variant after rofecoxib treatment; increased risk of colon cancer; decreased rate of myocardial infarction and stroke in Caucasians but an increased incidence in African Americans.
|Drugs=rofecoxib
|Drug Classes=
|Diseases=Colonic Neoplasms; Myocardial Infarction; Stroke
|Curation Level=Curated
|PharmGKB Accession ID=PA161145105
}}

{{PharmGKB
|RSID=rs20417
|Name_s=PTGS2:  -765G>C
|Gene_s=PTGS2
|Feature=
|Evidence=PubMed ID:15138244; PubMed ID:15150618; PubMed ID:15767339; PubMed ID:16678543; PubMed ID:17495879
|Annotation=Decreased anti-inflammatory and analgesic effects after mino dental surgery in patients with -765G>C variant after rofecoxib treatment; increased risk of colon cancer; decreased rate of myocardial infarction and stroke in caucasians but an increased incidence in african american.
|Drugs=rofecoxib
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161149022
}}

{{PharmGKB
|RSID=rs20417
|Name_s=COX-2 G-765C
|Gene_s=PTGS2
|Feature=
|Evidence=PubMed ID:17495879
|Annotation=Risk or phenotype-associated allele: C. Phenotype: COX-2 -765C showed a small nonsignificant association with higher risk of CHD in aspirin non-users and lower risk of CHD in those reporting aspirin use. Study size: 2362. Study population/ethnicity: Atherosclerosis Risk in Communities Study, ARIC study; African Americans; Whites; USA. Significance metric(s): HR = 1.36, 95% CI 0.97-1.90, p = 0.075 (non-users); HR = 0.60, 95% CI 0.36-1.02, p = 0.058 (users) Type of association: CO.
|Drugs=
|Drug Classes=
|Diseases=Coronary Disease
|Curation Level=Curated
|PharmGKB Accession ID=PA165291725
}}
{{PMID Auto
|PMID=21124790
|Title=The Functional -765G?C Polymorphism of the COX-2 Gene May Reduce the Risk of Developing Crohn's Disease
|OA=1
}}

{{PMID Auto
|PMID=21283657
|Title=Gallbladder Cancer Predisposition: A Multigenic Approach to DNA-Repair, Apoptotic and Inflammatory Pathway Genes
|OA=1
}}

{{PMID Auto
|PMID=22763923
|Title=Association of COX-2 rs20417 with aspirin resistance
}}

{{PMID|16046815|OA=1
}} Data-mining analysis suggests an epigenetic pathogenesis for type 2 diabetes.

{{PMID|16205694|OA=1
}} Allellic variants in regulatory regions of cyclooxygenase-2: association with advanced colorectal adenoma.

{{PMID|16879213}} Polymorphisms of prostaglandin-endoperoxide synthase 2 gene, and prostaglandin-E receptor 2 gene, C-reactive protein concentrations and risk of atherothrombosis: a nested case-control approach.

{{PMID|17171651}} Cyclooxygenase-2 polymorphisms in Parkinson's disease.

{{PMID|17181859|OA=1
}} Genetic polymorphisms in the cyclooxygenase-2 gene, use of nonsteroidal anti-inflammatory drugs, and breast cancer risk.

{{PMID|17214885|OA=1
}} A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study.

{{PMID|17234302}} Association of prostaglandin-endoperoxide synthase 2 (PTGS2) polymorphisms and Alzheimer's disease in Chinese.

{{PMID|18085997}} Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance.

{{PMID|18768181|OA=1
}} Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study.

{{PMID|18787196|OA=1
}} Segment-specific genetic effects on carotid intima-media thickness: the Northern Manhattan study.

{{PMID|18974063}} COX-2 promoter polymorphisms and the association with prostate cancer risk in South African men.

{{PMID|19197984|OA=1
}} Cyclooxygenase-2 gene polymorphisms reduce the risk of oral premalignant lesions.

{{PMID|19223558|OA=1
}} Polymorphic variation in NFKB1 and other aspirin-related genes and risk of Hodgkin lymphoma.

{{PMID|19318492|OA=1
}} Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk.

{{PMID|19437564|OA=1
}} No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk.

{{PMID|19625268}} The influence of COX-2 single nucleotide polymorphisms on abdominal aortic aneurysm development and the associated inflammation.

{{PMID|19930591|OA=1
}} Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study.

{{PMID|20406895|OA=1
}} Genetic variants in inflammation pathway genes and asthma in glioma susceptibility.

{{PMID|20599859}} Association of -765G>C polymorphism of the COX-2 gene with recurrent embryo implantation failure in Southern Chilean women.

{{PMID|20803508}} Cyclooxygenase-2 (COX-2) polymorphisms and risk of inflammatory bowel disease in a Scottish and Danish case-control study.

{{PMID|20811626|OA=1
}} Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

{{PMID|21042835}} Functional polymorphisms of cyclooxygenase-2 gene and risk for hepatocellular carcinoma.

{{PMID|21114363}} A polymorphism in the cyclooxygenase 2 gene in type 1 diabetic patients with nephropathy.

{{PMID|21304218}} Cyclooxygenase-2 polymorphisms and susceptibility to esophageal cancer: a meta-analysis.

{{PMID|21538574}} Interaction of cyclooxygenase-2 promoter polymorphisms with Helicobacter pylori infection and risk of gastric cancer.

{{PMID|21848701}} Functional genetic variations of cyclooxygenase-2 and susceptibility to acute myeloid leukemia in a Chinese population.

{{PMID|22023987}} Polymorphisms in COX-2 gene influence prostate cancer susceptibility in a northern Indian cohort.

{{PMID|22037828}} Polymorphisms in cycloxygenase-2 gene and breast cancer prognosis: association between PTGS2 haplotypes and histopathological features.

{{PMID|22100366}} Cyclooxygenase-2 -765G>C polymorphism is associated with C-reactive protein levels in resistant smokers but not in chronic obstructive pulmonary disease patients.

{{PMID|22487732}} Influence of COX-2 and OXTR polymorphisms on treatment outcome in treatment resistant depression.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs20417
|overall_frequency_n=30
|overall_frequency_d=128
|overall_frequency=0.234375
|n_genomes=24
|n_genomes_annotated=0
|n_haplomes=26
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23907768
|Title=Cyclooxygenase-2 Genetic Polymorphism and Stroke Subtypes in Chinese
}}

{{PMID Auto
|PMID=24022467
|Title=COX-1 (PTGS1) and COX-2 (PTGS2) polymorphisms, NSAID interactions, and risk of colon and rectal cancers in two independent populations
}}

{{PMID Auto
|PMID=23765972
|Title=Interaction between ALOX5AP-SG13S114A/T and COX-2-765G/C increases susceptibility to cerebral infarction in a Chinese population
}}

{{PMID Auto
|PMID=24194923
|Title=Interactions between Diet, Lifestyle and IL10, IL1B, and PTGS2/COX-2 Gene Polymorphisms in Relation to Risk of Colorectal Cancer in a Prospective Danish Case-Cohort Study
|OA=1
}}

{{PMID Auto
|PMID=24324075
|Title=Associations of Cyclooxygenase 2 Polymorphic Genotypes with Bladder Cancer Risk in Taiwan
}}

{{PMID Auto
|PMID=23029430
|Title=Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma.
|OA=1
}}

{{PMID Auto
|PMID=23852948
|Title=Cyclooxygenase 2 genetic polymorphism may increase the risk of developing leukoaraiosis in Chinese.
}}

{{PMID Auto
|PMID=24789723
|Title=Cyclooxygenase-2 Polymorphisms and Breast Cancer Associated Risk in Pakistani Patients
}}

{{PMID Auto
|PMID=25166592
|Title=Intestinal PTGS2 mRNA Levels, PTGS2 Gene Polymorphisms, and Colorectal Carcinogenesis
}}

{{PMID Auto
|PMID=25214704
|Title=Association of the Three Common SNPs of Cyclooxygenase-2 Gene (rs20417, rs689466, and rs5275) with the Susceptibility of Breast Cancer: An Updated Meta-Analysis Involving 34,590 Subjects
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}