{{Rsnum
|rsid=2043211
|Gene=CARD8
|Chromosome=19
|position=48234449
|Orientation=plus
|GMAF=0.331
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=CARD8
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 52.2 | 40.7 | 7.1
| HCB | 27.0 | 46.7 | 26.3
| JPT | 33.6 | 46.9 | 19.5
| YRI | 70.7 | 26.5 | 2.7
| ASW | 61.4 | 31.6 | 7.0
| CHB | 27.0 | 46.7 | 26.3
| CHD | 20.2 | 57.8 | 22.0
| GIH | 48.5 | 44.6 | 6.9
| LWK | 60.0 | 37.3 | 2.7
| MEX | 48.3 | 46.6 | 5.2
| MKK | 44.2 | 44.2 | 11.5
| TSI | 41.2 | 46.1 | 12.7
| HapMapRevision=28
}}{{omim
|desc=CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 8; CARD8
|id=609051
|rsnum=2043211
}}

{{PMID Auto
|PMID=20182451
|Title=Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn's disease
}}

{{PMID Auto
|PMID=21248762
|Title=Association of CARD8 with inflammatory bowel disease in Koreans
}}

{{PMID Auto
|PMID=21621776
|Title=Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysms
}}

{{PMID Auto
|PMID=18092344
|Title=No association of the CARD8 (TUCAN) c.30T>A (p.C10X) variant with Crohn's disease: a study in 3 independent European cohorts.
}}

{{PMID Auto
|PMID=18212821
|Title=Novel isoforms of the CARD8 (TUCAN) gene evade a nonsense mutation.
}}

{{PMID Auto
|PMID=18841008
|Title=Deficiency of CARD8 is associated with increased Alzheimer's disease risk in women.
}}

{{PMID Auto
|PMID=19664744
|Title=A genome-wide in vitro bacterial-infection screen reveals human variation in the host response associated with inflammatory disease.
|OA=1
}}

{{PMID Auto
|PMID=19843337
|Title=Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=22128899
|Title=Association study of CARD8 (p.C10X) and NLRP3 (p.Q705K) variants with rheumatoid arthritis in French and Tunisian populations.
}}

{{GET Evidence
|gene=CARD8
|aa_change=Cys10Stop
|aa_change_short=C10X
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2043211
|overall_frequency_n=3108
|overall_frequency_d=10758
|overall_frequency=0.288901
|n_genomes=34
|n_genomes_annotated=0
|n_haplomes=38
|n_articles=0
|n_articles_annotated=0
|nblosum100=10
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23088220
|Title=CARD8 rs2043211 (p.C10X) Polymorphism Is Not Associated with Disease Susceptibility or Cardiovascular Events in Spanish Rheumatoid Arthritis Patients
|OA=1
}}

{{PMID Auto
|PMID=23507658
|Title=Susceptibility to M tuberculosis infection in HIV-positive patients is associated with CARD8 genetic variant
}}

{{PMID Auto
|PMID=23547871
|Title=Genetic variants in CARD8 but not in NLRP3 are associated with ankylosing spondylitis
}}

{{PMID Auto
|PMID=24142982
|Title=Genes involved in innate immunity associated with asbestos-related fibrotic changes
|OA=1
}}

{{PMID Auto
|PMID=24295199
|Title=Association of NLRP3 and CARD8 genetic polymorphisms with juvenile idiopathic arthritis in a Taiwanese population
}}

{{PMID Auto
|PMID=24385277
|Title=Regulation of CARD8 Expression by ANRIL and Association of CARD8 Single Nucleotide Polymorphism rs2043211 (p.C10X) With Ischemic Stroke
}}

{{PMID Auto
|PMID=23171454
|Title=Genetic support for the role of the NLRP3 inflammasome in psoriasis susceptibility.
}}

{{PMID Auto
|PMID=23611467
|Title=CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}