{{Rsnum
|rsid=2046045
|Gene=PDE8B
|Chromosome=5
|position=77239986
|Orientation=minus
|GMAF=0.3664
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=PDE8B
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 31.0 | 51.3 | 17.7
| HCB | 1.5 | 27.0 | 71.5
| JPT | 4.4 | 21.2 | 74.3
| YRI | 5.0 | 27.9 | 67.1
| ASW | 5.4 | 44.6 | 50.0
| CHB | 1.5 | 27.0 | 71.5
| CHD | 0.9 | 25.7 | 73.4
| GIH | 20.0 | 57.0 | 23.0
| LWK | 3.7 | 23.9 | 72.5
| MEX | 15.5 | 50.0 | 34.5
| MKK | 1.3 | 32.7 | 66.0
| TSI | 40.2 | 47.1 | 12.7
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs2046045
|Name_s=
|Gene_s=PDE8B
|Feature=
|Evidence=PubMed ID:18514160
|Annotation=In a GWAS, this SNP showed strong association with levels of circulating Thyroid-stimulating hormone (TSH). The initial GWAS was done on 4300 Sardinians and the association was replicated in additional Sardinians plus Tuscan and Old Order Amish cohorts (4158 individuals).
|Drugs=
|Drug Classes=
|Diseases=Thyroid Diseases
|Curation Level=Curated
|PharmGKB Accession ID=PA161748313
}}

{{PMID Auto GWAS
|PMID=22494929
|Trait=None
|Title=Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function.
|RiskAllele=T
|Pval=3E-27
|OR=0.1150
|ORtxt=None
}}

{{PMID|19197348|OA=1
}} Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2046045
|overall_frequency_n=89
|overall_frequency_d=128
|overall_frequency=0.695312
|n_genomes=48
|n_genomes_annotated=0
|n_haplomes=77
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}