{{Rsnum
|rsid=2046934
|Gene=P2RY12
|Chromosome=3
|position=151339854
|Orientation=minus
|GMAF=0.1529
|Gene_s=MED12L,P2RY12
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 3.1 | 41.5 | 55.4
| HCB | 4.5 | 31.8 | 63.6
| JPT | 2.3 | 34.1 | 63.6
| YRI | 1.6 | 36.5 | 61.9
| ASW | 0.0 | 0.0 | 0.0
| CHB | 4.5 | 31.8 | 63.6
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

{{PMID|17707382}}  [[rs10935838]], [[rs2046934]], [[rs5853517]], and [[rs6809699]]  [[venous thromboembolism]] lower risk of incident DVT/PE as compared to the reference haplotype H1 (odds ratio=0.50, 95% CI=0.27-0.93, p=0.028)

{{PMID Auto
|PMID=19786296
|Title=Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction
}}

{{PharmGKB
|RSID=rs2046934
|Name_s=P2RY12:744T>C
|Gene_s=MED12L, P2RY12
|Feature=
|Evidence=Web Resource:http://www.pharmgkb.org/search/annotatedGene/p2ry12/variant.jsp
|Annotation=This SNP was used to tag the H2 haplotype to show association with peripherial arterial disease and coronary artery disease.
|Drugs=clopidogrel; ticlopidine
|Drug Classes=
|Diseases=
|Curation Level=In-Depth
|PharmGKB Accession ID=PA161845835
}}

{{PharmGKB
|RSID=rs2046934
|Name_s=P2RY1:T744C; P2RY1:i-T744C
|Gene_s=MED12L, P2RY12
|Feature=
|Evidence=PubMed ID:12912815; PubMed ID:14662702; PubMed ID:15795539; PubMed ID:16181985; PubMed ID:16405973; PubMed ID:16581111; PubMed ID:16769602; PubMed ID:16961627; PubMed ID:17337040; PubMed ID:17803810
|Annotation=This is one of four SNPs that comprise H1/H2 haplotypes. The four SNPs (C139T, T744C, ins801A, G52T(=G50T) are in perfect LD, and T744C is frequently used as the tagging SNP. H1 is 139C/744T/no ins at 801A/52G. H2(minor haplotype) is 139T/744C/ins801A//52T. H2 haplotype has been found to be associated with enhanced platelet reactivity, peripheral artery disease, coronary artery disease(particularly in non-smokers)and with poor response to clopidrogel. In other studies, no association was found between haplotype and response to clopidrogel or aspirin or with cardiovascular events.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145104
}}

{{PharmGKB
|RSID=rs2046934
|Name_s=P2RY12:T744C,P2RY12:i-T744C
|Gene_s=MED12L, P2RY12
|Feature=
|Evidence=PubMed ID:12912815; PubMed ID:14662702; PubMed ID:15795539; PubMed ID:16181985; PubMed ID:16405973; PubMed ID:16581111; PubMed ID:16769602; PubMed ID:16961627; PubMed ID:17337040; PubMed ID:17803810
|Annotation=This is one of four SNPs that comprise H1/H2 haplotypes. The four SNPs (C139T, T744C, ins801A, G52T(=G50T) are in perfect LD, and T744C is frequently used as the tagging SNP. H1 is 139C/744T/no ins at 801A/52G. H2(minor haplotype) is 139T/744C/ins801A//52T. H2 haplotype has been found to be associated with enhanced platelet reactivity, peripheral artery disease, coronary artery disease(particularly in non-smokers)and with poor response to clopidogrel. In other studies, no association was found between haplotype and response to clopidogrel or aspirin or with cardiovascular events.
|Drugs=aspirin; clopidogrel
|Drug Classes=
|Diseases=Coronary Artery Disease; Peripheral Vascular Diseases
|Curation Level=Curated
|PharmGKB Accession ID=PA161149141
}}

{{PMID Auto
|PMID=18213371
|Title=The P2Y 13 Met-158-Thr polymorphism, which is in linkage disequilibrium with the P2Y 12 locus, is not associated with acute myocardial infarction.
|OA=1
}}

{{PMID Auto
|PMID=20126830
|Title=The influence of variation in the P2Y12 receptor gene on in vitro platelet inhibition with the direct P2Y12 antagonist cangrelor.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2046934
|overall_frequency_n=101
|overall_frequency_d=126
|overall_frequency=0.801587
|n_genomes=52
|n_genomes_annotated=0
|n_haplomes=82
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}