{{Rsnum
|rsid=20541
|Gene=IL13
|Chromosome=5
|position=132660272
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.2681
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=IL13
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 60.2 | 36.3 | 3.5
| HCB | 43.1 | 44.5 | 12.4
| JPT | 48.7 | 42.5 | 8.8
| YRI | 70.1 | 25.2 | 4.8
| ASW | 61.4 | 36.8 | 1.8
| CHB | 43.1 | 44.5 | 12.4
| CHD | 50.5 | 38.5 | 11.0
| GIH | 63.4 | 31.7 | 5.0
| LWK | 60.0 | 34.5 | 5.5
| MEX | 25.9 | 55.2 | 19.0
| MKK | 76.9 | 21.8 | 1.3
| TSI | 66.7 | 26.5 | 6.9
| HapMapRevision=28
}}[[rs20541]] is a C/T polymorphism on the interleukin 13 gene [[IL13]] associated with IgE levels.

{{PMID|18186920|OA=1
}} [[rs20541]] influences the effect of maternal smoking during pregnancy and persistent childhood [[asthma]]

{{PMID|18417506}} [[rs1295685]] and [[rs20541]] were significantly associated with elevated IgE levels in pooled analyses. [[rs2569190]](T;T) and [[rs2569191]](C;C) genotypes associated with lower IgE

[http://blog.23andme.com/2009/01/26/snpwatch-new-psoriasis-snps-found-for-both-europeans-and-asians/ 23andMe blog] [[psoriasis]] 
Europeans [[rs20541]](G) 	1.27x risk 	

{{PMID Auto
|PMID=19254294
|Title=Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort.
}}

{{PMID Auto GWAS
|PMID=19169254
|Trait=Psoriasis
|Title=Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
|RiskAllele=G
|Pval=5E-15
|OR=1.27
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=19533685
|Title=Common genetic variants and risk for non-Hodgkin lymphoma and adult T-cell lymphoma/leukemia in Jamaica
}}

{{omim
|desc=PSORIASIS SUSCEPTIBILITY 11; PSORS11
|id=612599
|rsnum=20541
}}
{{PMID Auto
|PMID=19796199
|Title=Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease
}}

{{PharmGKB
|RSID=rs20541
|Name_s=
|Gene_s=IL13
|Feature=
|Evidence=PubMed ID:19169254; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. (Initial Sample Size: 1,359 cases, 1,400 controls; Replication Sample Size: 5,048 cases, 5,041 controls); (Region: 5q31.1; Reported Gene(s): IL13; Risk Allele: rs20541-G); (p-value= 0.000000000000005).This variant is associated with Psoriasis.
|Drugs=
|Drug Classes=
|Diseases=Psoriasis
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740037
}}

{{PMID Auto
|PMID=20332709
|Title=Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9 and IL-13 with Graves' disease
}}
{{PMID Auto
|PMID=20403202
|Title=Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: a prospective birth cohort study
|OA=1
}}
{{PMID Auto
|PMID=20975284
|Title=Case-Control Study of Eczema Associated with IL13 Genetic Polymorphisms in Japanese Children
}}
{{PMID Auto
|PMID=20484924
|Title=Interleukin 13 and interleukin 4 receptor-? polymorphisms in rhinitis and asthma
}}

{{PMID Auto
|PMID=21309855
|Title=A meta-analysis of Th2 pathway genetic variants and risk for allergic rhinitis
|OA=1
}}

{{omim
|id=147683
|rsnum=20541
|variant=0002
}}

{{PMID Auto
|PMID=21196282
|Title=Single nucleotide polymorphisms in IL-4Ra, IL-13 and STAT6 genes occurs in brain glioma
}}

{{PMID Auto
|PMID=22013915
|Title=IL13 genetic polymorphisms, smoking, and eczema in women: a case-control study in Japan
|OA=1
}}

{{PMID Auto
|PMID=22023794
|Title=Case-control study of IL13 polymorphisms, smoking, and rhinoconjunctivitis in Japanese women: the Kyushu Okinawa Maternal and Child Health Study
|OA=1
}}

{{PMID Auto
|PMID=22053598
|Title=Association of TGF-beta1, IL-4 and IL-13 gene polymerphisms with asthma in a Chinese population
}}

{{PMID Auto
|PMID=22286212
|Title=Genome-Wide Association Study of Classical Hodgkin Lymphoma and Epstein-Barr Virus Status-Defined Subgroups
|OA=1
}}

{{PMID Auto GWAS
|PMID=22075330
|Trait=None
|Title=A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.
|RiskAllele=A
|Pval=3E-18
|OR=0.0800
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=22419714
|Title=Effect of Type 2 Diabetes Predisposing Genetic Variants on Colorectal Cancer Risk
}}

{{PMID Auto
|PMID=22432974
|Title=Environmental tobacco smoke and male sex modify the influence of IL-13 genetic variants on cord blood IgE levels
}}

{{ClinVar
|rsid=20541
|Reversed=1
|FwdREF=T
|FwdALT=C
|REF=A
|ALT=G
|RSPOS=131995964
|CHROM=5
|GMAF=0.2683
|dbSNPBuildID=67
|SSR=0
|SAO=1
|VP=0x05036800000015051f130101
|GENEINFO=IL13:3596
|GENE_NAME=IL13
|GENE_ID=3596
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000005.9:g.131995964A>G
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=147683.0002
|CLNSIG=255
|CLNCUI=CN029238
|CLNDBN=Asthma, susceptibility to; Allergic rhinitis, susceptibility to
|Disease=Asthma; Allergic rhinitis
|CLNACC=RCV000015785.1; RCV000015786.1
|Tags=RV;PM;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;MTP;OM
|CAF=0.2681; 0.7319
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=C1869116:600807
|COMMON=1
}}

{{PMID Auto
|PMID=15660293
|Title=No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=15726497
|Title=Gene-environment interaction effects on the development of immune responses in the 1st year of life.
|OA=1
}}

{{PMID Auto
|PMID=16024651
|Title=Polymorphisms associated with asthma are inversely related to glioblastoma multiforme.
|OA=1
}}

{{PMID Auto
|PMID=16449530
|Title=Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=16702372
|Title=Associations of classic Kaposi sarcoma with common variants in genes that modulate host immunity.
}}

{{PMID Auto
|PMID=16759385
|Title=Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).
|OA=1
}}

{{PMID Auto
|PMID=16832637
|Title=Evaluation of interleukin 13 polymorphisms in systemic sclerosis.
}}

{{PMID Auto
|PMID=17135570
|Title=Localization of a long-range cis-regulatory element of IL13 by allelic transcript ratio mapping.
|OA=1
}}

{{PMID Auto
|PMID=17303794
|Title=Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma.
|OA=1
}}

{{PMID Auto
|PMID=17327408
|Title=Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
|OA=1
}}

{{PMID Auto
|PMID=17346294
|Title=IL13 gene polymorphism association with cord serum immunoglobulin E.
|OA=1
}}

{{PMID Auto
|PMID=17561245
|Title=Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood.
}}

{{PMID Auto
|PMID=17615386
|Title=IL13 promoter polymorphism 1112C/T modulates the adverse effect of tobacco smoking on lung function.
}}

{{PMID Auto
|PMID=17705862
|Title=Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
|OA=1
}}

{{PMID Auto
|PMID=18006935
|Title=An international case-control study of interleukin-4Ralpha, interleukin-13, and cyclooxygenase-2 polymorphisms and glioblastoma risk.
}}

{{PMID Auto
|PMID=18056382
|Title=Analysis of the 5q31 33 locus shows an association between single nucleotide polymorphism variants in the IL-5 gene and symptomatic infection with the human blood fluke, Schistosoma japonicum.
|OA=1
}}

{{PMID Auto
|PMID=18075513
|Title=Variants in the 5q31 cytokine gene cluster are associated with psoriasis.
}}

{{PMID Auto
|PMID=18410415
|Title=Polymorphisms in the interleukin 13 and GATA binding protein 3 genes and the development of eczema during childhood.
|OA=1
}}

{{PMID Auto
|PMID=18614543
|Title=The 5q31 variants associated with psoriasis and Crohn's disease are distinct.
|OA=1
}}

{{PMID Auto
|PMID=18633131
|Title=Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
|OA=1
}}

{{PMID Auto
|PMID=18676870
|Title=Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.
|OA=1
}}

{{PMID Auto
|PMID=18687755
|Title=Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.
|OA=1
}}

{{PMID Auto
|PMID=18778477
|Title=Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival.
|OA=1
}}

{{PMID Auto
|PMID=18846228
|Title=Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus.
|OA=1
}}

{{PMID Auto
|PMID=19066394
|Title=Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=19262574
|Title=Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis.
|OA=1
}}

{{PMID Auto
|PMID=19356949
|Title=Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.
|OA=1
}}

{{PMID Auto
|PMID=19554022
|Title=Association between IL13 polymorphisms and psoriatic arthritis is modified by smoking.
}}

{{PMID Auto
|PMID=19759553
|Title=Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort.
|OA=1
}}

{{PMID Auto
|PMID=19840389
|Title=Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria.
|OA=1
}}

{{PMID Auto
|PMID=19956101
|Title=Overview of the Rapid Response data.
|OA=1
}}

{{PMID Auto
|PMID=19956102
|Title=Evidence for association of the TCF7 locus with type I diabetes.
|OA=1
}}

{{PMID Auto
|PMID=19956106
|Title=Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families.
|OA=1
}}

{{PMID Auto
|PMID=19956109
|Title=The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.
|OA=1
}}

{{PMID Auto
|PMID=20015396
|Title=Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians.
|OA=1
}}

{{PMID Auto
|PMID=20298583
|Title=Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma.
|OA=1
}}

{{PMID Auto
|PMID=20358028
|Title=IL-13 Gene Polymorphisms are Associated With Rhinosinusitis and Eosinophilic Inflammation in Aspirin Intolerant Asthma.
|OA=1
}}

{{PMID Auto
|PMID=20406895
|Title=Genetic variants in inflammation pathway genes and asthma in glioma susceptibility.
|OA=1
}}

{{PMID Auto
|PMID=20606885
|Title=Genetics of psoriasis and psoriatic arthritis.
|OA=1
}}

{{PMID Auto
|PMID=20811626
|Title=Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
|OA=1
}}

{{PMID Auto
|PMID=20952689
|Title=Cytokine polymorphisms in Th1/Th2 pathway genes, body mass index, and risk of non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=21253569
|Title=Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations?
|OA=1
}}

{{PMID Auto
|PMID=21320344
|Title=Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.
|OA=1
}}

{{PMID Auto
|PMID=21349879
|Title=Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris.
|OA=1
}}

{{PMID Auto
|PMID=21613309
|Title=IL13 gene polymorphism is a marker for psoriatic arthritis among psoriasis patients.
}}

{{PMID Auto
|PMID=21913997
|Title=Association of polymorphisms in genes encoding IL-4, IL-13 and their receptors with atopic dermatitis in a Korean population.
}}

{{PMID Auto
|PMID=22045834
|Title=Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression.
}}

{{PMID Auto
|PMID=22201026
|Title=Genome-wide pathway analysis of a genome-wide association study on psoriasis and Behcet's disease.
}}

{{PMID Auto
|PMID=22222605
|Title=IL-13 polymorphisms contribute to the risk of asthma: a meta-analysis.
}}

{{PMID Auto
|PMID=22376040
|Title=Gene-gene interactions between candidate gene polymorphisms are associated with total IgE levels in Korean children with asthma.
}}

{{GET Evidence
|gene=IL13
|aa_change=Gln144Arg
|aa_change_short=Q144R
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs20541
|overall_frequency_n=8727
|overall_frequency_d=10758
|overall_frequency=0.81121
|n_genomes=52
|n_genomes_annotated=0
|n_haplomes=78
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=3
|qualitycomment_in_silico=Y
|in_gwas=Y
|in_pharmgkb=Y
|nblosum100=0
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22534877
|Title=Follow-up study of the first genome-wide association scan in alopecia areata: IL13 and KIAA0350 as susceptibility loci supported with genome-wide significance
}}

{{PMID Auto
|PMID=23171465
|Title=Association between non-atopic hand eczema and interleukin-13 gene polymorphism in Taiwanese nursing population
}}

{{PMID Auto
|PMID=23545317
|Title=Association of interleukin-13 SNP rs20541 with allergic rhinitis risk: a meta-analysis
}}

{{PMID Auto
|PMID=23617596
|Title=Genetic variants of the genes encoding zinc finger protein 313 and interleukin-13 confer a risk for psoriasis in a Chinese Uygur population
}}

{{PMID Auto
|PMID=23200760
|Title=Pathway analysis of genome-wide association study on asthma
}}

{{PMID Auto
|PMID=23299779
|Title=Interleukin-10 gene polymorphisms are associated with freedom from treatment failure for patients with Hodgkin lymphoma
|OA=1
}}

{{PMID Auto
|PMID=23267696
|Title=Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case-control study
|OA=1
}}

{{PMID Auto
|PMID=23954258
|Title=Association of Interleukin-13 SNP rs20541 (Arg&gt;Gln) to allergic rhinitis in an Asian population of ethnic Chinese in Singapore
}}

{{PMID Auto
|PMID=23978640
|Title=Association of IL-13 gene polymorphisms with airway hyperresponsiveness in a Japanese adult asthmatic population
}}

{{PMID Auto
|PMID=24286397
|Title=Association between the interleukin-13 gene and development of chronic obstructive pulmonary disease in southern Chinese Han population: a case-control study
}}

{{PMID Auto GWAS
  |PMID=23817569
  |Trait=Self-reported allergy
  |Title=A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
  |RiskAllele=A
  |Pval=1E-6
  |OR=.07
  |ORtxt=[0.043-0.101] unit increase
  |OA=1
}}

{{PMID Auto
|PMID=22694930
|Title=Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases.
|OA=1
}}

{{PMID Auto
|PMID=23246181
|Title=Association between IL13 gene polymorphisms and susceptibility to cancer: a meta-analysis.
}}

{{PMID Auto
|PMID=23395224
|Title=Association between polymorphisms in interleukin-4Ralpha and interleukin-13 and glioma risk: a meta-analysis.
}}

{{PMID Auto
|PMID=23462527
|Title=IL4R and IL13 polymorphic variants and development of antibodies to surface antigen of hepatitis B virus in hemodialysis patients in response to HBV vaccination or infection.
}}

{{PMID Auto
|PMID=23663310
|Title=Investigating highly replicated asthma genes as candidate genes for allergic rhinitis.
|OA=1
}}

{{PMID Auto
|PMID=23815671
|Title=Interactive effect of STAT6 and IL13 gene polymorphisms on eczema status: results from a longitudinal and a cross-sectional study.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}