{{Rsnum
|rsid=20572
|Gene=CBR1
|Chromosome=21
|position=36072675
|Orientation=plus
|GMAF=0.129
|Gene_s=AP000688.14,CBR1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 75.4 | 24.6 | 0.0
| HCB | 64.4 | 33.3 | 2.2
| JPT | 40.0 | 48.9 | 11.1
| YRI | 100.0 | 0.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 64.4 | 33.3 | 2.2
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs20572
|Name_s=627C>T; A209A
|Gene_s=CBR1, SETD4
|Feature=
|Evidence=PubMed ID:19016765
|Annotation=patients with ref CC genotype had significantly higher clearance of doxorubicin compared to CT patients, 24.07 CL/BSA vs 20.13 CL/BSA (P=0.028); patients with CC genotype had trend toward lower exposure levels vs CT patients, 15.44 AUC/dose/BSA vs 20.36 AUC/dose/BSA (P=0.066); patients with ref CC genotype had lower peak plasma concentration of doxorubicinol compared to CT patients 0.32 Cmax/dose/BSA vs 0.49 Cmas/dose/BSA (P=0.030) ; study population: patients with invasive breast cancer; study size=62; ethnicity Chinese (74%), Malays (18%) and Indians (8%)
|Drugs=doxorubicin
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165363187
}}

{{PMID Auto
|PMID=12958705
|Title=Genomewide linkage and linkage disequilibrium analyses identify COL6A1, on chromosome 21, as the locus for ossification of the posterior longitudinal ligament of the spine.
|OA=1
}}

{{PMID Auto
|PMID=17267408
|Title=Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells.
|OA=1
}}

{{PMID Auto
|PMID=17344335
|Title=A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}