{{Rsnum
|rsid=20576
|Gene=TNFRSF10A
|Chromosome=8
|position=23200707
|Orientation=minus
|ReferenceAllele=A
|MissenseAllele=C
|GMAF=0.1065
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=TNFRSF10A
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 58.4 | 38.1 | 3.5
| HCB | 97.1 | 2.9 | 0.0
| JPT | 99.1 | 0.9 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 92.9 | 7.1 | 0.0
| CHB | 97.1 | 2.9 | 0.0
| CHD | 97.2 | 2.8 | 0.0
| GIH | 79.2 | 20.8 | 0.0
| LWK | 98.2 | 1.8 | 0.0
| MEX | 70.7 | 27.6 | 1.7
| MKK | 73.7 | 24.4 | 1.9
| TSI | 64.7 | 29.4 | 5.9
| HapMapRevision=28
}}Carriers of an 228Ala allele for [[rs20576]] who have [[prostate cancer]] and are treated by radiation therapy have a higher risk (odds ratio 2.47, CI: 1.10-5.54, p=0.028) for subsequent metastasis. {{PMID|18163425}}

{{PMID Auto
|PMID=19643596
|Title=TRAIL-R1 polymorphisms and cancer susceptibility: An evidence-based meta-analysis
}}

{{PMID Auto
|PMID=21484799
|Title=Association of death receptor 4 variant (683A > C) with ovarian cancer risk in BRCA1 mutation carriers.
}}

{{GET Evidence
|gene=TNFRSF10A
|aa_change=Glu228Ala
|aa_change_short=E228A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs20576
|overall_frequency_n=1566
|overall_frequency_d=10758
|overall_frequency=0.145566
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=18
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.275
|nblosum100=3
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23658636
|Title=Candidate Gene Study of TRAIL and TRAIL Receptors: Association with Response to Interferon Beta Therapy in Multiple Sclerosis Patients
|OA=1
}}

{{PMID Auto
|PMID=24587306
|Title=Death Receptor (DR4) Haplotypes Are Associated with Increased Susceptibility of Gallbladder Carcinoma in North Indian Population
|OA=1
}}

{{PMID Auto
|PMID=25207117
|Title=A Study of the Impact of Death Receptor 4 (DR4) Gene Polymorphisms in Alzheimer's Disease
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}