{{Rsnum
|rsid=2066808
|Gene=STAT2
|Chromosome=12
|position=56344189
|Orientation=minus
|GMAF=0.1818
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=STAT2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 14.2 | 85.8
| HCB | 0.0 | 5.1 | 94.9
| JPT | 0.9 | 10.6 | 88.5
| YRI | 41.5 | 49.7 | 8.8
| ASW | 24.6 | 38.6 | 36.8
| CHB | 0.0 | 5.1 | 94.9
| CHD | 0.0 | 6.5 | 93.5
| GIH | 0.0 | 5.0 | 95.0
| LWK | 33.6 | 45.5 | 20.9
| MEX | 1.7 | 13.8 | 84.5
| MKK | 7.1 | 36.5 | 56.4
| TSI | 0.0 | 16.7 | 83.3
| HapMapRevision=28
}}[http://blog.23andme.com/2009/01/26/snpwatch-new-psoriasis-snps-found-for-both-europeans-and-asians/ 23andMe blog] [[psoriasis]] 
Europeans
*[[rs2066808]](A) 	1.34x risk

{{PMID Auto GWAS
|PMID=19169254
|Trait=Psoriasis
|Title=Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
|RiskAllele=A
|Pval=1E-9
|OR=1.34
|ORtxt=None
|OA=1
}}

{{PharmGKB
|RSID=rs2066808
|Name_s=
|Gene_s=STAT2
|Feature=
|Evidence=PubMed ID:19169254; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. (Initial Sample Size: 1,359 cases, 1,400 controls; Replication Sample Size: 5,048 cases, 5,041 controls); (Region: 12q13.2; Reported Gene(s): IL23A, STAT2; Risk Allele: rs2066808-A); (p-value= 0.000000001).This variant is associated with Psoriasis.
|Drugs=
|Drug Classes=
|Diseases=Psoriasis
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740043
}}

{{PMID Auto GWAS
|PMID=20953190
|Trait=None
|Title=A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
|RiskAllele=
|Pval=2E-7
|OR=1.4900
|ORtxt=[1.28-1.73]
|OA=1
}}

{{PMID Auto
|PMID=21623003
|Title=Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis
|OA=1
}}

{{PMID Auto
|PMID=20154336
|Title=Comprehensive sequence analysis of the human IL23A gene defines new variation content and high rate of evolutionary conservation.
|OA=1
}}

{{PMID Auto
|PMID=21253569
|Title=Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations?
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2066808
|overall_frequency_n=31
|overall_frequency_d=128
|overall_frequency=0.242188
|n_genomes=24
|n_genomes_annotated=0
|n_haplomes=34
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23579029
|Title=Protective effect of interleukin-23A (IL23A) haplotype variants on type 1A diabetes mellitus in a Brazilian population
}}

{{PMID Auto
|PMID=23673284
|Title=Association study in Romanians confirms IL23A gene haplotype block rs2066808/rs11171806 as conferring risk to psoriatic arthritis
}}

{{PMID Auto
|PMID=24957500
|Title=Genetic variation at IL12B, IL23R and IL23A is associated with psoriasis severity, psoriatic arthritis and type 2 diabetes mellitus
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}