{{Rsnum
|rsid=2066827
|Gene=CDKN1B
|Chromosome=12
|position=12718165
|Orientation=plus
|GMAF=0.2952
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=CDKN1B,LOC101929220
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 0.9 | 42.5 | 56.6
| HCB | 0.7 | 7.3 | 92.0
| JPT | 0.0 | 7.1 | 92.9
| YRI | 63.3 | 31.3 | 5.4
| ASW | 50.9 | 40.4 | 8.8
| CHB | 0.7 | 7.3 | 92.0
| CHD | 0.0 | 7.3 | 92.7
| GIH | 10.9 | 38.6 | 50.5
| LWK | 60.0 | 32.7 | 7.3
| MEX | 5.2 | 31.0 | 63.8
| MKK | 55.8 | 39.1 | 5.1
| TSI | 7.8 | 36.3 | 55.9
| HapMapRevision=28
}}{{PMID Auto
|PMID=20075119
|Title=Allelic variant at -79 (C&gt;T) in CDKNIB (p27Kip1) confers an increased risk of thyroid cancer and alters mRNA levels
}}

{{PMID Auto
|PMID=17409409
|Title=Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer.
}}

{{PMID Auto
|PMID=17459456
|Title=A common variant of the p16(INK4a) genetic region is associated with physical function in older people.
|OA=1
}}

{{PMID Auto
|PMID=18174243
|Title=Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population.
|OA=1
}}

{{PMID Auto
|PMID=18281541
|Title=Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival.
|OA=1
}}

{{PMID Auto
|PMID=18389087
|Title=Rarity of Somatic Mutation and Frequency of Normal Sequence Variation Detected in Sporadic Colon Adenocarcinoma Using High-Throughput cDNA Sequencing.
|OA=1
}}

{{PMID Auto
|PMID=18507837
|Title=Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort.
|OA=1
}}

{{PMID Auto
|PMID=18543099
|Title=No evidence that CDKN1B (p27) polymorphisms modify breast cancer risk in BRCA1 and BRCA2 mutation carriers.
}}

{{PMID Auto
|PMID=18547414
|Title=Genotyping panel for assessing response to cancer chemotherapy.
|OA=1
}}

{{PMID Auto
|PMID=19258477
|Title=Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19543528
|Title=Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer.
|OA=1
}}

{{PMID Auto
|PMID=19667240
|Title=p27kip1-838C>A single nucleotide polymorphism is associated with restenosis risk after coronary stenting and modulates p27kip1 promoter activity.
}}

{{GET Evidence
|gene=CDKN1B
|aa_change=Val109Gly
|aa_change_short=V109G
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2066827
|overall_frequency_n=4226
|overall_frequency_d=10742
|overall_frequency=0.393409
|n_genomes=33
|n_genomes_annotated=0
|n_haplomes=49
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=1
|qualitycomment_in_silico=Y
|gene_in_genetests=Y
|pph2_score=0.004
|genetests_testable=Y
|nblosum100=8
|autoscore=2
|n_web_uneval=9
}}

{{PMID Auto
|PMID=24920291
|Title=Association between the p27 rs2066827 variant and tumor multiplicity in patients harboring MEN1 germline mutations
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}