{{Rsnum
|rsid=2066842
|Gene=NOD2
|Chromosome=16
|position=50710713
|Orientation=plus
|GMAF=0.1249
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=NOD2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 39.3 | 53.6 | 7.1
| HCB | 99.3 | 0.7 | 0.0
| JPT | 98.2 | 1.8 | 0.0
| YRI | 97.9 | 2.1 | 0.0
| ASW | 78.9 | 17.5 | 3.5
| CHB | 99.3 | 0.7 | 0.0
| CHD | 98.2 | 1.8 | 0.0
| GIH | 85.0 | 14.0 | 1.0
| LWK | 97.2 | 2.8 | 0.0
| MEX | 63.2 | 35.1 | 1.8
| MKK | 82.6 | 16.1 | 1.3
| TSI | 56.9 | 38.2 | 4.9
| HapMapRevision=28
}}{{PMID Auto
|PMID=20595247
|Title=Polymorphisms of innate pattern recognition receptors, response to interferon-beta and development of neutralizing antibodies in multiple sclerosis patients
}}

{{PMID Auto
|PMID=16008671
|Title=Association of CARD15 polymorphisms with atopy-related traits in a population-based cohort of Caucasian adults.
}}

{{PMID Auto
|PMID=16600026
|Title=Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.
|OA=1
}}

{{PMID Auto
|PMID=17327408
|Title=Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
|OA=1
}}

{{PMID Auto
|PMID=18633131
|Title=Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
|OA=1
}}

{{PMID Auto
|PMID=18715515
|Title=Lack of evidence for association of primary sclerosing cholangitis and primary biliary cirrhosis with risk alleles for Crohn's disease in Polish patients.
|OA=1
}}

{{PMID Auto
|PMID=20698950
|Title=NOD2-C2 - a novel NOD2 isoform activating NF-kappaB in a muramyl dipeptide-independent manner.
|OA=1
}}

{{PMID Auto
|PMID=21304977
|Title=An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
|OA=1
}}

{{PMID Auto
|PMID=21745515
|Title=Role of NOD1/CARD4 and NOD2/CARD15 gene polymorphisms in cancer etiology.
}}

{{GET Evidence
|gene=NOD2
|aa_change=Pro268Ser
|aa_change_short=P268S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2066842
|overall_frequency_n=2123
|overall_frequency_d=10756
|overall_frequency=0.197378
|n_genomes=13
|n_genomes_annotated=0
|n_haplomes=16
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=3
|autoscore=2
|n_web_uneval=10
}}

{{PMID Auto
|PMID=23651603
|Title=P268S in NOD2 associates with susceptibility to Parkinson's disease in Chinese population
|OA=1
}}

{{PMID Auto
|PMID=22957492
|Title=Pathway analysis of a genome-wide association study of ileal Crohn's disease.
}}

{{PMID Auto
|PMID=23085276
|Title=NOD2 gene mutations associate weakly with ulcerative colitis but not with Crohn's disease in Indian patients with inflammatory bowel disease.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}