{{Rsnum
|rsid=2066843
|Gene=NOD2
|Chromosome=16
|position=50711288
|Orientation=plus
|ReferenceAllele=C
|GMAF=0.1295
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=NOD2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 40.5 | 53.2 | 6.3
| HCB | 99.3 | 0.7 | 0.0
| JPT | 99.1 | 0.9 | 0.0
| YRI | 97.3 | 2.7 | 0.0
| ASW | 78.6 | 17.9 | 3.6
| CHB | 99.3 | 0.7 | 0.0
| CHD | 99.1 | 0.9 | 0.0
| GIH | 86.9 | 13.1 | 0.0
| LWK | 90.9 | 9.1 | 0.0
| MEX | 65.5 | 32.8 | 1.7
| MKK | 73.1 | 25.0 | 1.9
| TSI | 57.4 | 36.6 | 5.9
| HapMapRevision=28
}}{{Report GE
|PubMed=17068223, 15571588
|Source=17554300
|AffyProbeset=SNP_A-1908244
|AffyOrientation=same
|AlleleA=C
|AlleleB=T
|onGW5=1
|rsid=2066843
|ancestral=C
|RiskPopulation=
|RiskAllele=T
|CaseFreq=0.38
|ControlFreq=
|OddsRatioHet=
|OddsRatioHom=
|OddsRatioAll=4.09
|Disease=Crohn's disease
|DiseaseSymbol=CD
}}

{{ neighbor
| rsid = 2066844
| distance = 727
}}

rs2066843 increases susceptibility to Crohn's disease 4.09 times for carriers of the T allele [PMID 17068223, 15571588]

{{PharmGKB
|RSID=rs2066843
|Name_s=
|Gene_s=NOD2, CARD15
|Feature=
|Evidence=PubMed ID:17068223
|Annotation=rs2066843 was found to be associated with Crohn's disease in GWAS of a European, non-Jewish case-control cohort.
|Drugs=
|Drug Classes=
|Diseases=Crohn Disease
|Curation Level=Curated
|PharmGKB Accession ID=PA161889366
}}

{{PMID Auto
|PMID=21209938
|Title=The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants
|OA=1
}}

{{PMID Auto
|PMID=16600026
|Title=Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.
|OA=1
}}

{{PMID Auto
|PMID=18576390
|Title=Autoinflammatory genes and susceptibility to psoriatic juvenile idiopathic arthritis.
|OA=1
}}

{{PMID Auto
|PMID=21304977
|Title=An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
|OA=1
}}

{{PMID Auto
|PMID=21745515
|Title=Role of NOD1/CARD4 and NOD2/CARD15 gene polymorphisms in cancer etiology.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2066843
|overall_frequency_n=2171
|overall_frequency_d=10756
|overall_frequency=0.201841
|n_genomes=15
|n_genomes_annotated=0
|n_haplomes=18
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23085276
|Title=NOD2 gene mutations associate weakly with ulcerative colitis but not with Crohn's disease in Indian patients with inflammatory bowel disease.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}