{{Rsnum
|rsid=2066847
|Gene=NOD2
|Chromosome=16
|position=50729867
|Orientation=plus
|GMAF=0.007805
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(-;-)
|geno2=(-;C)
|geno3=(C;C)
|Gene_s=NOD2
}}[[rs2066847]] is one of several SNPs referring to a one base insertion into a run of C's within exon 11 of the [[NOD2]] gene; the other SNPs are [[rs5743293]] and [[rs112436597]].

The two initial reports linking this insertion variant with [[Crohn's disease]] are {{PMID|11385576}} and {{PMID|11385577}}. In OMIM, this insertion is allelic variant [http://omim.org/entry/605956#0001 #605956.0001]

{{ neighbor
| rsid = 5743293
| distance = 3
}}

{{PMID Auto GWAS
|PMID=18587394
|Trait=Crohn's disease
|Title=Genome-wide assocation defines more than 30 distinct susceptibility loci for Crohn's disease
|RiskAllele=C
|Pval=3E-24
|OR=3.99
|ORtxt=[NR]
|OA=1
}}

{{PMID Auto GWAS
|PMID=20570966
|Trait=Crohn's disease
|Title=Fucosyltransferase 2(FUT2) Non-Secretor Status is associated with Crohn's Disease
|RiskAllele=
|Pval=2E-15
|OR=1.62
|ORtxt=[1.42-1.86]
|OA=1
}}
{{PMID Auto
|PMID=20940596
|Title=NOD2/CARD15 Mutations Correlate With Severe Pouchitis After Ileal Pouch-Anal Anastomosis
}}
{{PMID Auto
|PMID=20959815
|Title=NOD2 Gene Polymorphism rs2066844 Associates With Need for Combined Liver-Intestine Transplantation in Children With Short-Gut Syndrome
}}

{{PMID Auto
|PMID=21734346
|Title=High-resolution melting curve analysis for high-throughput genotyping of NOD2/CARD15 mutations and distribution of these mutations in Slovenian inflammatory bowel diseases patients
|OA=1
}}

{{PMID Auto
|PMID=22649567
|Title=Patients with Inflammatory Bowel Disease Exhibit Dysregulated Responses to Microbial DNA
|OA=1
}}

{{PMID Auto
|PMID=22719818
|Title=Inflammatory Bowel Diseases Phenotype, C. difficile and NOD2 Genotype Are Associated with Shifts in Human Ileum Associated Microbial Composition
|OA=1
}}

{{PMID Auto
|PMID=16380915
|Title=Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.
|OA=1
}}

{{PMID Auto
|PMID=16859562
|Title=Do host genetic traits in the bacterial sensing system play a role in the development of Chlamydia trachomatis-associated tubal pathology in subfertile women?
|OA=1
}}

{{PMID Auto
|PMID=17327408
|Title=Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
|OA=1
}}

{{PMID Auto
|PMID=17684544
|Title=Systematic association mapping identifies NELL1 as a novel IBD disease gene.
|OA=1
}}

{{PMID Auto
|PMID=17786191
|Title=rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.
|OA=1
}}

{{PMID Auto
|PMID=18070336
|Title=CD209 in inflammatory bowel disease: a case-control study in the Spanish population.
|OA=1
}}

{{PMID Auto
|PMID=18382655
|Title=Maternal TLR4 and NOD2 gene variants, pro-inflammatory phenotype and susceptibility to early-onset preeclampsia and HELLP syndrome.
|OA=1
}}

{{PMID Auto
|PMID=18633131
|Title=Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
|OA=1
}}

{{PMID Auto
|PMID=18698678
|Title=Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult- and pediatric-onset inflammatory bowel disease in Italy.
|OA=1
}}

{{PMID Auto
|PMID=19147066
|Title=Genomic and proteomic analysis of allogeneic hematopoietic cell transplant outcome. Seeking greater understanding the pathogenesis of GVHD and mortality.
|OA=1
}}

{{PMID Auto
|PMID=19185283
|Title=Searching for genotype-phenotype structure: using hierarchical log-linear models in Crohn disease.
|OA=1
}}

{{PMID Auto
|PMID=19843337
|Title=Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=20047977
|Title=Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium.
|OA=1
}}

{{PMID Auto
|PMID=20066736
|Title=Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn's disease patients.
|OA=1
}}

{{PMID Auto
|PMID=20082483
|Title=NOD2, IL23R and ATG16L1 polymorphisms in Lithuanian patients with inflammatory bowel disease.
|OA=1
}}

{{PMID Auto
|PMID=21304977
|Title=An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
|OA=1
}}

{{PMID Auto
|PMID=21730793
|Title=Influence of Crohn's disease risk alleles and smoking on disease location.
|OA=1
}}

{{PMID Auto GWAS
  |PMID=23128233
  |Trait=Crohn's disease
  |Title=Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
  |RiskAllele=T
  |Pval=6E-209
  |OR=3.10
  |ORtxt=[1.497-1.618]
  |OA=1
}}

{{PMID Auto
|PMID=23651603
|Title=P268S in NOD2 associates with susceptibility to Parkinson's disease in Chinese population
|OA=1
}}

{{PMID Auto |PMID=21745302 |Title=NOD2 gene variants are a risk factor for culture-positive spontaneous bacterial peritonitis and monomicrobial bacterascites in cirrhosis. }}

{{PMID Auto
|PMID=23725363
|Title=Predicting complicated Crohn's disease and surgery: phenotypes, genetics, serology and psychological characteristics of a population-based cohort.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}