{{Rsnum
|rsid=2066853
|Gene=AHR
|Chromosome=7
|position=17339486
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.2741
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=AHR
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.9 | 17.7 | 81.4
| HCB | 16.8 | 45.3 | 38.0
| JPT | 21.2 | 49.6 | 29.2
| YRI | 21.1 | 49.0 | 29.9
| ASW | 12.3 | 56.1 | 31.6
| CHB | 16.8 | 45.3 | 38.0
| CHD | 14.7 | 43.1 | 42.2
| GIH | 2.0 | 16.8 | 81.2
| LWK | 25.5 | 49.1 | 25.5
| MEX | 0.0 | 25.9 | 74.1
| MKK | 17.9 | 39.1 | 42.9
| TSI | 0.0 | 17.6 | 82.4
| HapMapRevision=28
}}[[rs2066853]] has been associated with increased risk for colorectal polyps depending on the amount of meat eaten or overall exposure to heterocyclic amines. {{PMID|18268115|OA=1
}}

{{PMID|18818557}}  [[lung cancer]] in a Chinese population heterozygous [[rs2158041]] OR=1.53 for GA vs compared with the (G;G) and [[rs7811989]] OR=1.48 for (G;A) compared with the GG genotype)
*[[rs2066853]] (p.Arg554Lys) and cumulative cigarette smoking and the Lys/Lys genotype conferred an increased risk of lung cancer in the heavy smokers OR=3.36

{{PMID Auto
|PMID=19415745
|Title=Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women
}}

{{PharmGKB
|RSID=rs2066853
|Name_s=AHR:R554K
|Gene_s=AHR
|Feature=
|Evidence=PubMed ID:11505220; PubMed ID:11866883; PubMed ID:12852830; PubMed ID:17498780
|Annotation=Very common variant with controversial associations.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145031
}}

{{PharmGKB
|RSID=rs2066853
|Name_s=AHR:554R>K
|Gene_s=AHR
|Feature=
|Evidence=Web Resource:http://www.pharmgkb.org/search/annotatedGene/ahr/variant.jsp
|Annotation=Conflicting studies have researched this variant in relationship to Alzheimer's, bladder cancer and lung cancer.
|Drugs=
|Drug Classes=
|Diseases=Alzheimer Disease; Lung Neoplasms; Urinary Bladder Neoplasms
|Curation Level=In-Depth
|PharmGKB Accession ID=PA161145212
}}

{{PMID Auto
|PMID=17160896
|Title=Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants.
|OA=1
}}

{{PMID Auto
|PMID=18545700
|Title=Mitochondrial DNA haplogroup D4a is a marker for extreme longevity in Japan.
|OA=1
}}

{{PMID Auto
|PMID=18632753
|Title=Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.
|OA=1
}}

{{PMID Auto
|PMID=18805939
|Title=Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
|OA=1
}}

{{PMID Auto
|PMID=18990750
|Title=Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=22211302
|Title=The association of functional polymorphisms in the aryl hydrocarbon receptor (AHR) gene with the risk of vitiligo in Han Chinese populations.
}}

{{GET Evidence
|gene=AHR
|aa_change=Arg554Lys
|aa_change_short=R554K
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2066853
|overall_frequency_n=2385
|overall_frequency_d=10758
|overall_frequency=0.221695
|n_genomes=28
|n_genomes_annotated=0
|n_haplomes=33
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|nblosum100=-3
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23168330
|Title=Genetic susceptibility to dioxin-like chemicals' induction of cytochrome P4501A2 in the human adult linked to specific AhRR polymorphism
}}

{{PMID Auto
|PMID=23528250
|Title=Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women
}}

{{PMID Auto
|PMID=23703535
|Title=Polymorphisms in Aryl Hydrocarbon Receptor Gene Are Associated With Idiopathic Male Factor Infertility
}}

{{PMID Auto
|PMID=22539616
|Title=Contributions of aryl hydrocarbon receptor genetic variants to the risk of glioma and PAH-DNA adducts.
}}

{{PMID Auto
|PMID=23492909
|Title=Pharmacogenetics of CYP1A2 activity and inducibility in smokers and exsmokers.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}