{{Rsnum
|rsid=2069830
|Gene=IL6
|Chromosome=7
|position=22727518
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.01837
|Gene_s=IL6,MIR632
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 100.0 | 0.0 | 0.0
| HCB | 99.3 | 0.7 | 0.0
| JPT | 99.1 | 0.9 | 0.0
| YRI | 83.0 | 17.0 | 0.0
| ASW | 78.9 | 21.1 | 0.0
| CHB | 99.3 | 0.7 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 86.4 | 13.6 | 0.0
| MEX | 98.3 | 1.7 | 0.0
| MKK | 92.3 | 7.7 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

{{PMID|18727828|OA=1
}} [[stroke]] [[rs2069830]](T) (frequency = 5%)  protective among non-smokers (OR = 0.30, 95% CI=0.11-.082, p=0.02), but not among smokers (OR = 1.63, 95% CI=0.48-5.58, p=0.43)

{{ neighbor
| rsid = 1800795
| distance = 492
}}
{{ neighbor
| rsid = 2069832
| distance = 296
}}

{{PMID Auto
|PMID=19387461
|Title=Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection
|OA=1
}}

{{PMID Auto
|PMID=18496509
|Title=An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients.
|OA=1
}}

{{PMID Auto
|PMID=19267250
|Title=C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.
|OA=1
}}

{{PMID Auto
|PMID=19503017
|Title=Genetic ancestry modifies pharmacogenetic gene-gene interaction for asthma.
|OA=1
}}

{{PMID Auto
|PMID=19729864
|Title=Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study.
|OA=1
}}

{{GET Evidence
|gene=IL6
|aa_change=Pro32Ser
|aa_change_short=P32S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2069830
|overall_frequency_n=283
|overall_frequency_d=10758
|overall_frequency=0.026306
|n_genomes=2
|n_genomes_annotated=0
|n_haplomes=2
|n_articles=0
|n_articles_annotated=0
|nblosum100=3
|autoscore=2
|n_web_uneval=10
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}