{{Rsnum
|rsid=2069837
|Gene=IL6
|Chromosome=7
|position=22728408
|Orientation=plus
|GMAF=0.1065
|Gene_s=IL6,MIR632
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 85.0 | 14.2 | 0.9
| HCB | 64.2 | 34.3 | 1.5
| JPT | 77.9 | 21.2 | 0.9
| YRI | 69.4 | 28.6 | 2.0
| ASW | 75.4 | 22.8 | 1.8
| CHB | 64.2 | 34.3 | 1.5
| CHD | 68.8 | 29.4 | 1.8
| GIH | 80.2 | 18.8 | 1.0
| LWK | 87.3 | 11.8 | 0.9
| MEX | 86.2 | 12.1 | 1.7
| MKK | 78.8 | 17.9 | 3.2
| TSI | 81.4 | 16.7 | 2.0
| HapMapRevision=28
}}In a study of 1,757 cases of [[Alzheimer's disease]] and 6,295 controls, an interaction was replicated between [[IL6]] genotype [[rs2069837]](A;A) and [[IL10]] genotype [[rs1800871]](C;C). The synergy factor (SF) was 1.63 (CI: 1.10-2.41, p = 0.01), controlling for age, gender and [[ApoE4]] genotype.{{PMID|19698145|OA=1
}}

{{PMID Auto
|PMID=22272811
|Title=Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease
|OA=1
}}

{{PMID Auto
|PMID=17847004
|Title=Common variants in the BMP2, BMP4, and HJV genes of the hepcidin regulation pathway modulate HFE hemochromatosis penetrance.
|OA=1
}}

{{PMID Auto
|PMID=18216863
|Title=Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.
|OA=1
}}

{{PMID Auto
|PMID=18436879
|Title=Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health Study.
|OA=1
}}

{{PMID Auto
|PMID=18496509
|Title=An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients.
|OA=1
}}

{{PMID Auto
|PMID=18500540
|Title=Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach.
|OA=1
}}

{{PMID Auto
|PMID=19267250
|Title=C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.
|OA=1
}}

{{PMID Auto
|PMID=19387461
|Title=Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection.
|OA=1
}}

{{PMID Auto
|PMID=19401628
|Title=Host genetics, steatosis and insulin resistance among African Americans and Caucasian Americans with hepatitis C virus genotype-1 infection.
|OA=1
}}

{{PMID Auto
|PMID=19729864
|Title=Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study.
|OA=1
}}

{{PMID Auto
|PMID=23088295
|Title=A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels
}}

{{PMID Auto
|PMID=23180271
|Title=Polymorphisms of the Interleukin 6 gene contribute to cervical cancer susceptibility in Eastern Chinese women
}}

{{PMID Auto
|PMID=23415255
|Title=Association of Interleukin 6 gene polymorphisms with genetic susceptibilities to spastic tetraplegia in males: a case-control study
}}

{{PMID Auto
|PMID=24903966
|Title=The association between sex-related interleukin-6 gene polymorphisms and the risk for cerebral palsy
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}