{{Rsnum
|rsid=2070045
|Gene=SORL1
|Chromosome=11
|position=121577381
|Orientation=plus
|ReferenceAllele=T
|GMAF=0.3214
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=SORL1
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 5.4 | 39.3 | 55.4
| HCB | 35.0 | 44.5 | 20.4
| JPT | 20.4 | 51.3 | 28.3
| YRI | 0.7 | 9.5 | 89.8
| ASW | 0.0 | 19.3 | 80.7
| CHB | 35.0 | 44.5 | 20.4
| CHD | 32.1 | 49.5 | 18.3
| GIH | 23.8 | 53.5 | 22.8
| LWK | 2.7 | 25.5 | 71.8
| MEX | 22.4 | 39.7 | 37.9
| MKK | 1.9 | 34.6 | 63.5
| TSI | 4.0 | 28.7 | 67.3
| HapMapRevision=28
}}SNP [[rs2070045]], a variant of the [[SORL1]] gene, has been reported to be associated with [[Alzheimer's disease]]. {{PMID|17220890|OA=1
}}

However, a subsequent study of over 2,000 patients found a weak (at best) association. {{PMID|17949987|OA=1
}}

{{PMID Auto
|PMID=18562096
|Title=No association of SORL1 SNPs with Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=18713574
|Title=The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=18938222
|Title=Allelic mRNA expression of sortilin-1 (SORL1) mRNA in Alzheimer's autopsy brain tissues.
|OA=1
}}

{{PMID Auto
|PMID=19064752
|Title=Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease.
|OA=1
}}

{{PMID Auto
|PMID=19362127
|Title=Endophenotypes in normal brain morphology and Alzheimer's disease: a review.
|OA=1
}}

{{PMID Auto
|PMID=19368828
|Title=Association of SORL1 gene variants with Alzheimer's disease.
}}

{{PMID Auto
|PMID=19906263
|Title=Use of genetic variation as biomarkers for Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=20061642
|Title=Use of genetic variation as biomarkers for mild cognitive impairment and progression of mild cognitive impairment to dementia.
|OA=1
}}

{{PMID Auto
|PMID=20574532
|Title=Intermediate phenotypes identify divergent pathways to Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=20625269
|Title=Amyloid-beta-Related Genes SORL1 and ACE are Genetically Associated With Risk for Late-onset Alzheimer Disease in the Chinese Population.
}}

{{PMID Auto
|PMID=24083537
|Title=SORL1 genetic variants modulate risk of amnestic mild cognitive impairment in northern Han Chinese
}}

{{PMID Auto
|PMID=24309291
|Title=Association between the SORL1 rs2070045 polymorphism and Late-onset Alzheimer's disease: Interaction with the ApoE genotype in the Chinese Han population
}}

{{PMID Auto
|PMID=23318115
|Title=Sortilin receptor 1 predicts longitudinal cognitive change.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}