{{Rsnum
|rsid=2070600
|Gene=AGER
|Chromosome=6
|position=32183666
|Orientation=minus
|GMAF=0.07438
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=AGER
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.9 | 9.7 | 89.4
| HCB | 5.1 | 37.2 | 57.7
| JPT | 0.9 | 23.9 | 75.2
| YRI | 0.0 | 1.4 | 98.6
| ASW | 0.0 | 3.5 | 96.5
| CHB | 5.1 | 37.2 | 57.7
| CHD | 3.7 | 35.8 | 60.6
| GIH | 1.0 | 15.8 | 83.2
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 2.6 | 97.4
| TSI | 0.0 | 2.9 | 97.1
| HapMapRevision=28
}}
[[rs2070600]] (Gly82Ser) is a non-synonymous snp located in exon 3 of [[AGER]] (Advanced Glycation End product Receptor). The somewhat more common (G) allele encodes for Glycine (Gly), while the minor (A) allele encodes for Serine (Ser).

{{PMID|18519797}} compared to Gly/Gly genotypes, Gly/Ser and Ser/Ser genotypes associated with significantly higher (adj. OR = 1.47, 95% CI 1.05-2.06, p = 0.0038) chance of [[gastric cancer]] in a sample of 566 Chinese individuals (283 cases, 283 age matched controls).

{{PMID|17224333}} in a sample of 1096 Korean men and 580 Korean women...
*serum soluble AGER (sRAGE) levels were significantly (p < .001) higher in individuals with Gly/Gly genotypes (1038 +/- 33 pg/mL), compared to Gly/Ser (809 +/- 19 pg/mL) or Ser/Ser genotypes (428 +/- 43 pg/mL).
*subjects with Ser/Ser genotypes showed higher levels of serum AGE, HOMA-IR levels (insulin resistance model), plasma TNF-alpha, serum CRP, and 8-epi-prostaglandin F2 alpha.

{{PMID|15803111}} [[type-1 diabetes| type-1 diabetics]] (487 t1ds and 351 controls) carrying the Ser allele associated with higher odds of advanced nephropathy (adj. OR = 3.17, 95% CI 1.32-7.85, p = 0.008)

{{PMID Auto
|PMID=19902324
|Title=Association between the RAGE G82S polymorphism and Alzheimer's disease
}}
{{PMID Auto GWAS
|PMID=20010834
|Trait=Lung function
|Title=Genome-wide association study identifies five loci associated with lung function
|RiskAllele=T
|Pval=3E-15
|OR=0.09
|ORtxt=[NR] % variance explained
|OA=1
}}

{{PMID Auto GWAS
|PMID=20010835
|Trait=Pulmonary function
|Title=Meta-analyses of genome-wide assocation studies identify multiple loci associated with pulmonary function
|RiskAllele=T
|Pval=3E-14
|OR=1.00
|ORtxt=[NR] % increase
|OA=1
}}

{{PMID Auto
|PMID=20567859
|Title=Association of the RAGE G82S polymorphism with Alzheimer's disease
|OA=1
}}
{{PMID Auto
|PMID=21067572
|Title=Association Analysis of Nine Candidate Gene Polymorphisms in Indian Patients with Type 2 Diabetic Retinopathy
|OA=1
}}

{{PMID Auto
|PMID=21298413
|Title=Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes
}}
{{PMID Auto
|PMID=21311028
|Title=The functional -374T/A polymorphism of the receptor for advanced glycation end products (RAGE) may modulate Crohn's disease
}}

{{PMID Auto
|PMID=21521347
|Title=Association of AGER gene G82S polymorphism with the severity of coronary artery disease in Chinese Han population
}}

{{PMID Auto
|PMID=22133449
|Title=Polymorphisms of the promoter and exon 3 of the receptor for advanced glycation end products (RAGE) in Euro- and Afro-Brazilians
}}

{{PMID Auto
|PMID=18796298
|Title=Polymorphisms in advanced glycosylation end product-specific receptor (AGER) gene, insulin resistance, and type 2 diabetes mellitus.
}}

{{PMID Auto
|PMID=19890027
|Title=Association of polymorphism in the receptor for advanced glycation end products (RAGE) gene with circulating RAGE levels.
}}

{{PMID Auto
|PMID=21304900
|Title=Individual and cumulative effects of GWAS susceptibility loci in lung cancer: associations after sub-phenotyping for COPD.
|OA=1
}}

{{PMID Auto
|PMID=21804548
|Title=Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.
}}

{{PMID Auto
|PMID=22146151
|Title=Is the Gly82Ser polymorphism in the RAGE gene relevant to schizophrenia and the personality trait psychoticism?
|OA=1
}}

{{GET Evidence
|gene=AGER
|aa_change=Gly82Ser
|aa_change_short=G82S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2070600
|overall_frequency_n=248
|overall_frequency_d=7510
|overall_frequency=0.0330226
|n_genomes=5
|n_genomes_annotated=0
|n_haplomes=5
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.983
|nblosum100=2
|autoscore=3
|n_web_uneval=10
}}

{{PMID Auto GWAS
  |PMID=23284291
  |Trait=Pulmonary function (interaction)
  |Title=Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
  |RiskAllele=
  |Pval=1E-21
  |OR=NR
  |ORtxt=NR
  |OA=1
}}

{{PMID Auto
|PMID=23267696
|Title=Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case-control study
|OA=1
}}

{{PMID Auto
|PMID=24286382
|Title=Association of five genetic variants with chronic obstructive pulmonary disease susceptibility and spirometric phenotypes in a Chinese Han population
}}

{{PMID Auto
|PMID=24605038
|Title=RAGE gene three polymorphisms with Crohn's disease susceptibility in Chinese Han population
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}