{{Rsnum
|rsid=2070874
|Gene=IL4
|Chromosome=5
|position=132674018
|Orientation=plus
|GMAF=0.4279
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=IL4
}}[[rs2070874]] is a SNP in the promoter region of the interleukin 4 [[IL4]] gene.

This SNP is one of five SNPs reported to be useful in a SNP set defining the risk of dying from [[prostate cancer]] among patients with the disease; see [[gs242]] and [[gs243]].

{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 74.3 | 23.9 | 1.8
| HCB | 5.1 | 42.3 | 52.6
| JPT | 7.1 | 40.7 | 52.2
| YRI | 27.2 | 55.8 | 17.0
| ASW | 38.6 | 47.4 | 14.0
| CHB | 5.1 | 42.3 | 52.6
| CHD | 6.4 | 36.7 | 56.9
| GIH | 78.2 | 18.8 | 3.0
| LWK | 18.2 | 47.3 | 34.5
| MEX | 37.9 | 46.6 | 15.5
| MKK | 48.1 | 39.1 | 12.8
| TSI | 76.5 | 19.6 | 3.9
| HapMapRevision=28
}}{{PMID|17713557|OA=1
}} Visceral leishmaniasis (VL) caused by Leishmania chagasi is endemic to northeast Brazil. A positive delayed-type hypersensitivity skin test response (DTH+) is a marker for acquired resistance to disease. the DTH- phenotype was associated with SNP [[rs2070874]] at IL4 (OR 3.14; P=0.006; 95% CI=1.38-7.14), and SNP [[rs30740]] between LECT2 and TGFBI (OR 3.00; P=0.042; 95% CI=1.04-8.65)

{{ neighbor
| rsid = 2243250
| distance = 556
}}

{{PMID Auto
|PMID=19254294
|Title=Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort.
}}

{{PMID Auto
|PMID=19058298
|Title=Promoter polymorphisms of IL2, IL4, and risk of gastric cancer in a high-risk Chinese population
}}

{{PMID Auto
|PMID=20032229
|Title=Prediction of functional impairment and remission in rheumatoid arthritis patients by biochemical variables and genetic polymorphisms
}}

{{PMID Auto
|PMID=20332709
|Title=Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9 and IL-13 with Graves' disease
}}
{{PMID Auto
|PMID=20921925
|Title=Effect of single nucleotide polymorphisms within the interleukin-4 promoter on aspirin intolerance in asthmatics and interleukin-4 promoter activity
}}

{{PMID Auto
|PMID=22053598
|Title=Association of TGF-beta1, IL-4 and IL-13 gene polymerphisms with asthma in a Chinese population
}}

{{PMID Auto
|PMID=22377791
|Title=Association of genetic polymorphisms of interleukins with new-onset diabetes after transplantation in renal transplantation
}}

{{PMID Auto
|PMID=15570643
|Title=Epistatic interactions between HLA-DRB1 and interleukin 4, but not interferon-gamma, increase susceptibility to giant cell arteritis.
}}

{{PMID Auto
|PMID=15660293
|Title=No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=16449530
|Title=Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=17303794
|Title=Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma.
|OA=1
}}

{{PMID Auto
|PMID=17327408
|Title=Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
|OA=1
}}

{{PMID Auto
|PMID=18056382
|Title=Analysis of the 5q31 33 locus shows an association between single nucleotide polymorphism variants in the IL-5 gene and symptomatic infection with the human blood fluke, Schistosoma japonicum.
|OA=1
}}

{{PMID Auto
|PMID=18454680
|Title=Genetic basis for adverse events after smallpox vaccination.
|OA=1
}}

{{PMID Auto
|PMID=18538381
|Title=Clinical and genetic risk factors of self-reported penicillin allergy.
}}

{{PMID Auto
|PMID=18633131
|Title=Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
|OA=1
}}

{{PMID Auto
|PMID=18676870
|Title=Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.
|OA=1
}}

{{PMID Auto
|PMID=18781131
|Title=Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma.
|OA=1
}}

{{PMID Auto
|PMID=19066394
|Title=Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=19356949
|Title=Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.
|OA=1
}}

{{PMID Auto
|PMID=19468064
|Title=Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.
|OA=1
}}

{{PMID Auto
|PMID=19840389
|Title=Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria.
|OA=1
}}

{{PMID Auto
|PMID=20015396
|Title=Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians.
|OA=1
}}

{{PMID Auto
|PMID=20525402
|Title=Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study.
|OA=1
}}

{{PMID Auto
|PMID=20811626
|Title=Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
|OA=1
}}

{{PMID Auto
|PMID=21320344
|Title=Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.
|OA=1
}}

{{PMID Auto
|PMID=21387019
|Title=Differences in candidate gene association between European ancestry and African American asthmatic children.
|OA=1
}}

{{PMID Auto
|PMID=21501388
|Title=Association between interleukin-4 gene polymorphisms and intracerebral haemorrhage in Korean population.
}}

{{PMID Auto
|PMID=22528336
|Title=Association study of interleukin-4 polymorphisms with paranoid schizophrenia in the Polish population: a critical approach.
}}

{{PMID Auto
|PMID=23572437
|Title=Three common polymorphisms in the IL-4 gene and cancer risk: A meta-analysis involving 5,392 cases and 6,930 controls
}}

{{PMID Auto
|PMID=23651591
|Title=Association of polymorphisms in the interleukin-4 gene with response to hepatitis B vaccine and susceptibility to hepatitis B virus infection: a meta-analysis
}}

{{PMID Auto
|PMID=23654077
|Title=IL-4 gene polymorphisms and their association with atopic asthma and allergic rhinitis in Pakistani patients
}}

{{PMID Auto
|PMID=23668806
|Title=Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns
|OA=1
}}

{{PMID Auto
|PMID=23924473
|Title=Association between the polymorphisms of interleukin-4, the interleukin-4 receptor gene and asthma
}}

{{PMID Auto
|PMID=23964553
|Title=Relationship between polymorphisms in IL4 and asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health Study
}}

{{PMID Auto
|PMID=24463336
|Title=Association of Interleukin-4 genetic polymorphisms with sporadic Alzheimer's disease in Chinese Han population
}}

{{PMID Auto
|PMID=22573572
|Title=Phenotype-genotype profiles in Crohn's disease predicted by genetic markers in autophagy-related genes (GOIA study II).
}}

{{PMID Auto
|PMID=22824342
|Title=Association of polymorphisms of cytokine and TLR-2 genes with long-term immunity to hepatitis B in children vaccinated early in life.
}}

{{PMID Auto
|PMID=22884982
|Title=Polymorphisms in the IL4 gene, smoking, and rhinoconjunctivitis in Japanese women: the Kyushu Okinawa Maternal and Child Health Study.
}}

{{PMID Auto
|PMID=23459936
|Title=Exploring the genetic basis of chronic periodontitis: a genome-wide association study.
|OA=1
}}

{{PMID Auto
|PMID=23663310
|Title=Investigating highly replicated asthma genes as candidate genes for allergic rhinitis.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}