{{Rsnum
|rsid=2070995
|Gene=KCNJ6
|Chromosome=21
|position=37714662
|Orientation=minus
|GMAF=0.1979
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=KCNJ6
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 5.3 | 29.2 | 65.5
| HCB | 19.1 | 42.6 | 38.2
| JPT | 11.5 | 50.4 | 38.1
| YRI | 0.0 | 0.7 | 99.3
| ASW | 1.8 | 3.5 | 94.7
| CHB | 19.1 | 42.6 | 38.2
| CHD | 13.8 | 57.8 | 28.4
| GIH | 2.0 | 30.0 | 68.0
| LWK | 0.0 | 1.8 | 98.2
| MEX | 5.3 | 38.6 | 56.1
| MKK | 0.6 | 3.2 | 96.2
| TSI | 3.9 | 34.3 | 61.8
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs2070995
|Name_s=
|Gene_s=KCNJ6
|Feature=
|Evidence=PubMed ID:20220551
|Annotation=Risk or phenotype-associated genotype: AA. Phenotype: The average methadone dose during the first year of substitution therapy were significantly larger in AA carriers (n=4) than in the other rs2070995 genotypes (p=0.003). Study Size: 85. Study population: Caucasian.
|Drugs=methadone
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165291728
}}

{{PharmGKB
|RSID=rs2070995
|Name_s=
|Gene_s=KCNJ6
|Feature=
|Evidence=PubMed ID:19756153
|Annotation=Risk or phenotype-associated allele: A. Phenotype: In an association study of subjects who underwent major open abdominal surgery, the A/A genotype in the A1032G SNP and -1250G (rs6517442)/1032A haplotype were significantly associated with increased postoperative analgesic requirements compared with other genotypes and haplotypes Study size: 129. Study population/ethnicity: Japanese. Type of association: GN.
|Drugs=morphine
|Drug Classes=
|Diseases=Pain
|Curation Level=Curated
|PharmGKB Accession ID=PA165109685
}}

{{PMID|20943350}} Epistatic interaction of CREB1 and KCNJ6 on rumination and negative emotionality.

{{PMID|21423693|OA=1
}} Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2070995
|overall_frequency_n=7995
|overall_frequency_d=9546
|overall_frequency=0.837524
|n_genomes=52
|n_genomes_annotated=0
|n_haplomes=92
|n_articles=2
|n_articles_annotated=2
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}