{{Rsnum
|rsid=2071746
|Gene=HMOX1
|Chromosome=22
|position=35380679
|Orientation=plus
|GMAF=0.4995
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=HMOX1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 35.4 | 38.5 | 26.2
| HCB | 33.3 | 35.6 | 31.1
| JPT | 27.3 | 50.0 | 22.7
| YRI | 11.1 | 38.1 | 50.8
| ASW | 0.0 | 0.0 | 0.0
| CHB | 33.3 | 35.6 | 31.1
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}A case-control study of 300 patients with [[Alzheimer's disease]] found that subjects carrying both the [[rs2071746]](T;T) and [[rs242557]](A;A) genotypes had a 6.65x increased risk (CI: 1.12-39.29; p = 0.037) compared to subjects without these risk genotypes.{{PMID|18841019}}

This combination of SNPs is encapsulated in the [[gs124]] [[genoset]].

{{PMID Auto
|PMID=20039940
|Title=Synergistic effect of two oxidative stress-related genes (heme oxygenase-1 and GSK3beta) on the risk of Parkinson's disease
}}

{{PMID Auto
|PMID=20509889
|Title=The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study
|OA=1
}}
{{PMID Auto
|PMID=20190330
|Title=HMOX1 and GST variants modify attenuation of FEF25-75% decline due to PM10 reduction
}}
{{PMID Auto
|PMID=21191307
|Title=Heme oxygenase-1 polymorphism is not associated with riskof colorectal cancer: a Danish prospective study
}}

{{PMID Auto
|PMID=21902835
|Title=Effect of Heme Oxygenase-1 Polymorphisms on Lung Function and Gene Expression
|OA=1
}}

{{PMID Auto
|PMID=22666428
|Title=Genetic Analyses of Heme Oxygenase 1 (HMOX1) in Different Forms of Pancreatitis
|OA=1
}}

{{PMID Auto
|PMID=18597895
|Title=Gene-gene interaction between heme oxygenase-1 and liver X receptor-beta and Alzheimer's disease risk.
}}

{{PMID Auto
|PMID=18640487
|Title=Association of donor inflammation- and apoptosis-related genotypes and delayed allograft function after kidney transplantation.
|OA=1
}}

{{PMID Auto
|PMID=19406964
|Title=Association of genetic variants with chronic kidney disease in Japanese individuals.
|OA=1
}}

{{PMID Auto
|PMID=19526221
|Title=Heme oxygenase-1 microsatellite polymorphism and haplotypes are associated with the development of acute respiratory distress syndrome.
|OA=1
}}

{{PMID Auto
|PMID=20597111
|Title=Effect of interactions of glutathione S-transferase T1, M1, and P1 and HMOX1 gene promoter polymorphisms with heavy smoking on the risk of rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=21270830
|Title=Cystic fibrosis modifier genes related to Pseudomonas aeruginosa infection.
}}

{{PMID Auto
|PMID=21275653
|Title=Association of heme oxygenase-1 gene polymorphisms with essential hypertension and blood pressure in the Chinese Han population.
}}

{{PMID Auto
|PMID=23042203
|Title=Gene polymorphisms in the heme degradation pathway and outcome of severe human sepsis
}}

{{PMID Auto
|PMID=23725037
|Title=Polymorphism in the HMOX1 Gene is Associated with High Levels of Fetal Hemoglobin in Brazilian Patients with Sickle Cell Anemia
}}

{{PMID Auto
|PMID=22609818
|Title=Genetic polymorphisms of HO-1 and COX-1 are associated with aspirin resistance defined by light transmittance aggregation in Chinese Han patients
}}

{{PMID Auto
|PMID=25016572
|Title=Association of heme oxygenase-1 gene rs2071746 polymorphism with vascular outcomes in patients with atherosclerotic stroke
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}