{{Rsnum
|rsid=2072493
|Gene=TLR5
|Chromosome=1
|position=223111257
|Orientation=minus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.1657
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=TLR5
}}{{omim
|desc=LEGIONNAIRE DISEASE, SUSCEPTIBILITY TO
|id=603031
|rsnum=2072493
|variant=0002
}}
{{ neighbor
| rsid = 5744168
| distance = 601
}}

{{ population diversity
| geno1 = (A;A)
| geno2 = (A;G)
| geno3 = (G;G)
| CEU | 70.0 | 30.0 | 0.0
| CHB | 55.6 | 33.3 | 11.1
| JPT | 31.1 | 55.6 | 13.3
| YRI | 100.0 | 0.0 | 0.0
}}

{{ClinVar
|rsid=2072493
|Reversed=1
|FwdREF=A
|FwdALT=G
|REF=T
|ALT=C
|RSPOS=223111257
|CHROM=1
|GMAF=0.1658
|dbSNPBuildID=96
|SSR=0
|SAO=1
|VP=0x050368000a15150516110100
|GENEINFO=TLR5:7100
|GENE_NAME=TLR5
|GENE_ID=7100
|WGT=1
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000001.11:g.223111257T>C
|CLNSRC=ClinVar; OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=NM_003268.5:c.1775A>G; 603031.0002
|CLNSIG=255
|CLNCUI=C1837872
|CLNDBN=Legionellosis
|Disease=Legionellosis
|CLNACC=RCV000007039.1
|Tags=RV;PM;PMC;S3D;SLO;NSM;REF;OTH;ASP;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;LSD;OM
|CAF=0.8343; 0.1657
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=C1837872:608556
|COMMON=1
}}

{{PMID|18396467|OA=1
}} Genetic variation and haplotype structures of innate immunity genes in eastern India.

{{PMID|19505919|OA=1
}} Toll-like receptor signaling pathway variants and prostate cancer mortality.

{{PMID|19543401|OA=1
}} Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.

{{GET Evidence
|gene=TLR5
|aa_change=Asn592Ser
|aa_change_short=N592S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2072493
|overall_frequency_n=1234
|overall_frequency_d=10758
|overall_frequency=0.114705
|n_genomes=17
|n_genomes_annotated=0
|n_haplomes=16
|n_articles=0
|n_articles_annotated=0
|in_omim=Y
|nblosum100=0
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}