{{Rsnum
|rsid=2072661
|Gene=CHRNB2
|Chromosome=1
|position=154576404
|Orientation=plus
|GMAF=0.2782
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CHRNB2
}}{{PharmGKB
|RSID=rs2072661
|Name_s=
|Gene_s=CHRNB2
|Feature=
|Evidence=PubMed ID:18593715
|Annotation=This variant is associated with success rate of smoking cessation. Individuals carrying the minor allele have substantially decreased odds of quitting (OR = 0.31; 95% CI 0.18-0.55). This variant is in the 3' UTR region of CHRNB2 genes, and may have a role in the time to relapse and an impact on withdrawal symptoms at target quit date.
|Drugs=nicotine
|Drug Classes=
|Diseases=Tobacco Use Disorder
|Curation Level=Curated
|PharmGKB Accession ID=PA161925504
}}
{{PMID Auto
|PMID=19482438
|Title=Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence
}}

{{PMID Auto
|PMID=15154117
|Title=A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men.
|OA=1
}}

{{PMID Auto
|PMID=17503330
|Title=A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence.
|OA=1
}}

{{PMID Auto
|PMID=18165968
|Title=Identification of pharmacogenetic markers in smoking cessation therapy.
|OA=1
}}

{{PMID Auto
|PMID=18534558
|Title=Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence.
|OA=1
}}

{{PMID Auto
|PMID=19238175
|Title=New insights into the genetics of addiction.
|OA=1
}}

{{PMID Auto
|PMID=19755656
|Title=Nicotinic acetylcholine receptor beta2 subunit (CHRNB2) gene and short-term ability to quit smoking in response to nicotine patch.
|OA=1
}}

{{PMID Auto
|PMID=22180580
|Title=Association Between Nicotinic Acetylcholine Receptor Single Nucleotide Polymorphisms and Smoking Cessation.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2072661
|overall_frequency_n=35
|overall_frequency_d=128
|overall_frequency=0.273438
|n_genomes=28
|n_genomes_annotated=0
|n_haplomes=30
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}