{{Rsnum
|rsid=2073618
|Gene=TNFRSF11B
|Chromosome=8
|position=118951813
|Orientation=minus
|GMAF=0.3567
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=COLEC10,TNFRSF11B
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 29.2 | 49.2 | 21.5
| HCB | 9.1 | 50.0 | 40.9
| JPT | 7.0 | 30.2 | 62.8
| YRI | 0.0 | 14.3 | 85.7
| ASW | 0.0 | 0.0 | 0.0
| CHB | 9.1 | 50.0 | 40.9
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID Auto
|PMID=20231205
|Title=Genetic Variations in Genes Encoding RANK, RANKL, and OPG in Rheumatoid Arthritis: A Case-Control Study
}}

{{PMID Auto
|PMID=22079369
|Title=TNFRSF11B gene haplotype and its association with bone mineral density variations in postmenopausal Mexican-Mestizo women
}}

{{PMID Auto
|PMID=21964949
|Title=Influence of polymorphisms in the RANKL/RANK/OPG signaling pathway on volumetric bone mineral density and bone geometry at the forearm in men
|OA=1
}}

{{PMID Auto
|PMID=16583245
|Title=Genetic susceptibility to hip arthroplasty failure--association with the RANK/OPG pathway.
|OA=1
}}

{{PMID Auto
|PMID=19458885
|Title=Association analyses of RANKL/RANK/OPG gene polymorphisms with femoral neck compression strength index variation in Caucasians.
|OA=1
}}

{{PMID Auto
|PMID=20205168
|Title=Genetic variation in the RANKL/RANK/OPG signaling pathway is associated with bone turnover and bone mineral density in men.
}}

{{PMID Auto
|PMID=21396799
|Title=Genetic polymorphisms and other risk factors associated with bisphosphonate induced osteonecrosis of the jaw.
}}

{{PMID Auto
|PMID=21411255
|Title=TNFRSF11B gene polymorphisms 1181G > C and 245T > G as well as haplotype CT influence bone mineral density in postmenopausal women.
}}

{{GET Evidence
|gene=TNFRSF11B
|aa_change=Asn3Lys
|aa_change_short=N3K
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2073618
|overall_frequency_n=6350
|overall_frequency_d=10706
|overall_frequency=0.593125
|n_genomes=38
|n_genomes_annotated=0
|n_haplomes=62
|n_articles=0
|n_articles_annotated=0
|nblosum100=1
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23369128
|Title=Genetic polymorphism of the OPG gene associated with breast cancer
|OA=1
}}

{{PMID Auto
|PMID=24130145
|Title=Polymorphism of LRP5, but not of TNFRSF11B, is associated with a decrease in bone mineral density in postmenopausal maya-mestizo women
}}

{{PMID Auto
|PMID=24228244
|Title=SNP rs2073618 of the Osteoprotegerin Gene Is Associated with Diabetic Retinopathy in Slovenian Patients with Type 2 Diabetes
|OA=1
}}

{{PMID Auto
|PMID=24283361
|Title=Association Between Seven Common OPG Genetic Polymorphisms and Osteoporosis Risk: A Meta-Analysis
}}

{{PMID Auto
|PMID=23299915
|Title=Osteoprotegerin gene rs2073617 and rs3134069 polymorphisms in type 2 diabetes patients and sexspecific rs2073618 polymorphism as a risk factor for diabetic foot.
}}

{{PMID Auto
|PMID=23531404
|Title=Association of genetic polymorphisms of RANK, RANKL and OPG with bone mineral density in Chinese peri- and postmenopausal women.
}}

{{PMID Auto
|PMID=25032118
|Title=Exclusion of TNFRSF11B as Candidate Gene for Otosclerosis in Campania Population
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}