{{Rsnum
|rsid=2073658
|Gene=USF1
|Chromosome=1
|position=161040972
|Orientation=minus
|GMAF=0.2158
|Gene_s=TSTD1,USF1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{omim
|desc=HYPERLIPIDEMIA, FAMILIAL COMBINED, SUSCEPTIBILITY TO
|id=191523
|rsnum=2073658
|variant=0002
}}

{{PMID|18097648}} [[rs2073658]] a borderline association with metabolic syndrome was observed (p = 0.036, IDF), the minor allele being the risk-increasing allele. The minor allele of rs2073658 also associated with higher total and LDL-cholesterol, apolipoprotein B-100 and lipoprotein(a) concentrations in longitudinal analyses.

{{PMID|18445538}} rs2073658 is associated with a modestly increased risk to develop [[type 2 diabetes]] in Dutch Caucasians, with considerable impact at the population level.

{{PMID Auto
|PMID=20031629
|Title=Functional Variant Disrupts Insulin Induction of USF1: Mechanism for USF1-Associated Dyslipidemias
}}

{{PMID Auto
|PMID=22460558
|Title=Potential Role of Upstream Stimulatory Factor 1 Gene Variant in Familial Combined Hyperlipidemia and Related Disorders
}}

{{PMID Auto
|PMID=15657872
|Title=Association testing in a linked region using large pedigrees.
|OA=1
}}

{{PMID Auto
|PMID=15959806
|Title=Upstream stimulatory factor 1 associated with familial combined hyperlipidemia, LDL cholesterol, and triglycerides.
}}

{{PMID Auto
|PMID=15976322
|Title=Familial combined hyperlipidemia in Mexicans: association with upstream transcription factor 1 and linkage on chromosome 16q24.1.
}}

{{PMID Auto
|PMID=16186412
|Title=Common polymorphisms in the USF1 gene are not associated with type 2 diabetes in French Caucasians.
}}

{{PMID Auto
|PMID=16699592
|Title=Risk alleles of USF1 gene predict cardiovascular disease of women in two prospective studies.
|OA=1
}}

{{PMID Auto
|PMID=18276913
|Title=Association analysis of allelic variants of USF1 in coronary atherosclerosis.
|OA=1
}}

{{PMID Auto
|PMID=18303204
|Title=Body mass index is associated with USF1 haplotype in Korean premenopausal women.
|OA=1
}}

{{PMID Auto
|PMID=18974842
|Title=Gender differences in genetic risk profiles for cardiovascular disease.
|OA=1
}}

{{ClinVar
|ALT=T
|CHROM=1
|CLNACC=RCV000013089.1
|CLNALLE=1
|CLNDBN=Hyperlipidemia, familial combined, susceptibility to
|CLNHGVS=NC_000001.11:g.161040972C>T
|CLNORIGIN=1
|CLNSIG=255
|CLNSRC=ClinVar; OMIM Allelic Variant
|CLNSRCID=NM_001113205.1:c.-2083G>A; NM_007122.4:c.561-100G>A; 191523.0002
|Disease=Hyperlipidemia
|FwdALT=A
|FwdREF=G
|GENEINFO=TSTD1:100131187; USF1:7391
|GENE_ID=100131187; 7391
|GENE_NAME=TSTD1; USF1
|REF=C
|RSPOS=161040972
|Reversed=1
|SAO=0
|SSR=0
|Tags=RV;PM;PMC;SLO;INT;R5;ASP;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;OM
|VC=SNV
|VP=0x0501680a000517051e010100
|WGT=1
|dbSNPBuildID=96
|rsid=2073658
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}