{{Rsnum
|rsid=2073838
|Gene=SLC22A4
|Chromosome=5
|position=132313529
|Orientation=plus
|GMAF=0.1318
|Gene_s=MIR4750,SLC22A4
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.9 | 16.8 | 82.3
| HCB | 7.3 | 31.4 | 61.3
| JPT | 10.7 | 43.8 | 45.5
| YRI | 0.0 | 13.0 | 87.0
| ASW | 1.8 | 8.8 | 89.5
| CHB | 7.3 | 31.4 | 61.3
| CHD | 8.3 | 34.9 | 56.9
| GIH | 0.0 | 15.8 | 84.2
| LWK | 0.9 | 8.3 | 90.8
| MEX | 0.0 | 10.5 | 89.5
| MKK | 0.0 | 5.8 | 94.2
| TSI | 1.0 | 13.7 | 85.3
| HapMapRevision=28
}}{{PMID|18709696}} [[rs2073838]] and [[rs3792876]] replicated for [[rheumatoid arthritis]] in Japanese, but not Caucasian populations.

{{PharmGKB
|RSID=rs2073838
|Name_s=
|Gene_s=SLC22A4
|Feature=
|Evidence=PubMed ID:18709696
|Annotation=In a replication study in a Japanese population and a metaanalysis of 9 studies confirmed an association of this SNP in the SLC22A4 gene with rheumatoid arthritis in Japanese population. The associations in Caucasian studies were not significant.
|Drugs=
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Curated
|PharmGKB Accession ID=PA162191342
}}

{{PMID Auto
|PMID=16380915
|Title=Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.
|OA=1
}}

{{PMID Auto
|PMID=16519819
|Title=Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.
|OA=1
}}

{{PMID Auto
|PMID=18466472
|Title=Constructing gene association networks for rheumatoid arthritis using the backward genotype-trait association (BGTA) algorithm.
|OA=1
}}

{{PMID Auto
|PMID=18466513
|Title=Evaluating gene x gene and gene x smoking interaction in rheumatoid arthritis using candidate genes in GAW15.
|OA=1
}}

{{PMID Auto
|PMID=18466554
|Title=Analyses of single marker and pairwise effects of candidate loci for rheumatoid arthritis using logistic regression and random forests.
|OA=1
}}

{{PMID Auto
|PMID=19956108
|Title=Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1.
|OA=1
}}

{{PMID Auto
|PMID=20018049
|Title=Evaluation of an optimal receiver operating characteristic procedure.
|OA=1
}}

{{PMID Auto
|PMID=20018071
|Title=Allelic based gene-gene interactions in rheumatoid arthritis.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2073838
|overall_frequency_n=11
|overall_frequency_d=128
|overall_frequency=0.0859375
|n_genomes=11
|n_genomes_annotated=0
|n_haplomes=14
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}