{{Rsnum
|rsid=2075252
|Gene=LRP2
|Chromosome=2
|position=169154475
|Orientation=minus
|GMAF=0.258
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=LRP2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 3.5 | 42.5 | 54.0
| HCB | 32.6 | 47.4 | 20.0
| JPT | 26.8 | 56.2 | 17.0
| YRI | 1.4 | 12.2 | 86.4
| ASW | 0.0 | 24.6 | 75.4
| CHB | 32.6 | 47.4 | 20.0
| CHD | 33.0 | 42.2 | 24.8
| GIH | 4.0 | 20.0 | 76.0
| LWK | 0.9 | 20.0 | 79.1
| MEX | 5.2 | 32.8 | 62.1
| MKK | 0.0 | 22.6 | 77.4
| TSI | 4.9 | 33.3 | 61.8
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs2075252
|Name_s=
|Gene_s=LRP2
|Feature=
|Evidence=PubMed ID:17457342
|Annotation=A study on 50 subjects (25 patients who developed a distinct hearing loss during cisplatin therapy and in 25 patients without hearing impairment after cisplatin therapy)observed a higher frequency of the A-allele of rs2075252 in the LRP2 in the group with hearing impairment than in the group with normal hearing after cisplatin therapy.
|Drugs=cisplatin
|Drug Classes=
|Diseases=nephrotoxicity; Ototoxicity
|Curation Level=Curated
|PharmGKB Accession ID=PA162263540
}}

{{PMID Auto
|PMID=18559602
|Title=Association of megalin genetic polymorphisms with prostate cancer risk and prognosis.
|OA=1
}}

{{PMID Auto
|PMID=22170372
|Title=Vitamin D receptor and megalin gene polymorphisms and their associations with longitudinal cognitive change in US adults.
|OA=1
}}

{{GET Evidence
|gene=LRP2
|aa_change=Lys4094Glu
|aa_change_short=K4094E
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2075252
|overall_frequency_n=8595
|overall_frequency_d=10758
|overall_frequency=0.79894
|n_genomes=50
|n_genomes_annotated=0
|n_haplomes=80
|n_articles=2
|n_articles_annotated=2
|gene_in_genetests=Y
|in_pharmgkb=Y
|genetests_reviewed=Y
|nblosum100=0
|autoscore=3
|webscore=N
|n_web_uneval=3
|summary_short=Associated with hearing loss with cisplatin.
}}

{{PMID Auto
|PMID=23274376
|Title=Cisplatin-induced ototoxicity in pediatric solid tumors: the role of glutathione S-transferases and megalin genetic polymorphisms
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}