{{Rsnum
|rsid=2075800
|Gene=HSPA1L
|Chromosome=6
|position=31810169
|Orientation=minus
|GMAF=0.2906
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=HSPA1L
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 14.2 | 38.9 | 46.9
| HCB | 10.9 | 40.9 | 48.2
| JPT | 23.9 | 42.5 | 33.6
| YRI | 0.0 | 0.7 | 99.3
| ASW | 0.0 | 14.0 | 86.0
| CHB | 10.9 | 40.9 | 48.2
| CHD | 11.0 | 50.5 | 38.5
| GIH | 6.9 | 39.6 | 53.5
| LWK | 0.0 | 1.8 | 98.2
| MEX | 13.8 | 58.6 | 27.6
| MKK | 0.6 | 8.3 | 91.0
| TSI | 11.8 | 54.9 | 33.3
| HapMapRevision=28
}}{{omim
|desc=SARCOIDOSIS, SUSCEPTIBILITY TO, 1; SS1
|id=181000
|rsnum=2075800
}}

{{omim
|desc=HEAT-SHOCK 70-KD PROTEIN-LIKE 1; HSPA1L
|id=140559
|rsnum=2075800
}}

{{PharmGKB
|RSID=rs2075800
|Name_s=HSPA1L: G>A (E602K)
|Gene_s=HSPA1L, HSPA1A, LSM2
|Feature=
|Evidence=PubMed ID:16538176
|Annotation=Risk or phenotype-associated allele: G allele (602Glu). Phenotype: Carbamazepine (CBZ)-induced hypersensitivity syndrome (HSS). Study size: 157. Study population/ethnicity: 13 CBZ-induced HSS cases and 144 CBZ-tolerant controls of Chinese descent. Significance metric(s): p = 0.001173, OR = 7.31. Type of association: GN; PD; TOX; ADR.
|Drugs=carbamazepine
|Drug Classes=
|Diseases=Drug Hypersensitivity
|Curation Level=Curated
|PharmGKB Accession ID=PA165291963
}}

{{PMID|16820586|OA=1
}} Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

{{PMID|17591867}} Association between heat shock protein 70/Hom genetic polymorphisms and uveitis in patients with sarcoidosis.

{{PMID|17601350|OA=1
}} A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

{{PMID|19409079|OA=1
}} Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 risk alleles in a family-based and a case control study.

{{PMID|20018025|OA=1
}} Genome-wide analysis of haplotype interaction for the data from the North American Rheumatoid Arthritis Consortium.

{{PMID|20714140}} Association of polymorphisms of heat shock protein 70 with susceptibility to noise-induced hearing loss in the Taiwanese population.

{{GET Evidence
|gene=HSPA1L
|aa_change=Glu602Lys
|aa_change_short=E602K
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2075800
|overall_frequency_n=2552
|overall_frequency_d=10758
|overall_frequency=0.237219
|n_genomes=24
|n_genomes_annotated=0
|n_haplomes=26
|n_articles=1
|n_articles_annotated=1
|in_pharmgkb=Y
|pph2_score=0.001
|nblosum100=0
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22922572
|Title=Heat shock protein 70 gene polymorphisms in sudden sensorineural hearing loss
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | Illumina Human 1M}}