{{Rsnum
|rsid=2076756
|Gene=NOD2
|Chromosome=16
|position=50722970
|Orientation=plus
|GMAF=0.1148
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=NOD2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 42.7 | 50.0 | 7.3
| HCB | 99.3 | 0.7 | 0.0
| JPT | 99.1 | 0.9 | 0.0
| YRI | 97.3 | 2.7 | 0.0
| ASW | 86.0 | 8.8 | 5.3
| CHB | 99.3 | 0.7 | 0.0
| CHD | 99.1 | 0.9 | 0.0
| GIH | 85.1 | 13.9 | 1.0
| LWK | 90.0 | 10.0 | 0.0
| MEX | 67.2 | 31.0 | 1.7
| MKK | 72.3 | 27.1 | 0.6
| TSI | 59.8 | 36.3 | 3.9
| HapMapRevision=28
}}[[rs2076756]] is a SNP of the [[NOD2]] gene found in a genome-wide association study to be associated with [[Crohn's disease]].

In several European populations, the minor [[NOD2]] allele, [[rs2076756]](G), is associated with increased risk for [[Crohn's disease]]. The odds ratio (pooled over several populations) is 1.71 (CI: 1.42-2.05, p=6x10<sup>-8</sup>).{{PMID|17684544|OA=1
}}

{{ neighbor
| rsid = 2066845
| distance = 341
}}

{{PMID Auto GWAS
|PMID=17435756
|Trait=Crohn's disease
|Title=Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
|RiskAllele=
|Pval=7.0000000000000005E-14
|OR=NR
|ORtxt=NR
|OA=1
}}
{{PMID Auto GWAS
|PMID=17068223
|Trait=Inflammatory bowel disease
|Title=A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
|RiskAllele=
|Pval=5.0000000000000003E-10
|OR=NR
|ORtxt=NR
}}

{{PharmGKB
|RSID=rs2076756
|Name_s=
|Gene_s=NOD2, CARD15
|Feature=
|Evidence=PubMed ID:17068223
|Annotation=rs2076756 was found to be associated with Crohn's disease in GWAS of a European, non-Jewish case-control cohort.
|Drugs=
|Drug Classes=
|Diseases=Crohn Disease
|Curation Level=Curated
|PharmGKB Accession ID=PA161889367
}}

{{PMID Auto GWAS
|PMID=21102463
|Trait=None
|Title=Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
|RiskAllele=G
|Pval=4E-69
|OR=1.5300
|ORtxt=[1.46-1.60]
|OA=1
}}

{{PMID Auto
|PMID=21209938
|Title=The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants
|OA=1
}}

{{PMID Auto GWAS
|PMID=22412388
|Trait=None
|Title=A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
|RiskAllele=G
|Pval=1E-37
|OR=1.6600
|ORtxt=None
|OA=1
}}

{{PMID|16600026|OA=1
}} Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.

{{PMID|18758464|OA=1
}} Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.

{{PMID|19408013|OA=1
}} Strategies and issues in the detection of pathway enrichment in genome-wide association studies.

{{PMID|19434077|OA=1
}} Detecting gene-gene interactions that underlie human diseases.

{{PMID|21745515}} Role of NOD1/CARD4 and NOD2/CARD15 gene polymorphisms in cancer etiology.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2076756
|overall_frequency_n=19
|overall_frequency_d=128
|overall_frequency=0.148438
|n_genomes=15
|n_genomes_annotated=0
|n_haplomes=18
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=22936669
  |Trait=Crohn's disease
  |Title=A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.
  |RiskAllele=G
  |Pval=3E-10
  |OR=1.46
  |ORtxt=[NR]
  }}

{{PMID Auto
|PMID=23725363
|Title=Predicting complicated Crohn's disease and surgery: phenotypes, genetics, serology and psychological characteristics of a population-based cohort.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}