{{Rsnum
|rsid=208294
|Gene=P2RX7
|Chromosome=12
|position=121162450
|Orientation=minus
|GMAF=0.4614
|Gene_s=P2RX7
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 17.7 | 55.8 | 26.5
| HCB | 39.7 | 46.3 | 14.0
| JPT | 33.6 | 44.2 | 22.1
| YRI | 11.1 | 38.1 | 50.8
| ASW | 0.0 | 0.0 | 0.0
| CHB | 39.7 | 46.3 | 14.0
| CHD | 25.7 | 56.0 | 18.3
| GIH | 38.6 | 40.6 | 20.8
| LWK | 7.4 | 25.9 | 66.7
| MEX | 44.8 | 46.6 | 8.6
| MKK | 21.4 | 37.7 | 40.9
| TSI | 28.4 | 41.2 | 30.4
| HapMapRevision=28
}}{{PMID Auto
|PMID=22623165
|Title=NEUROTICISM MEDIATES THE EFFECT OF P2RX7 ON OUTCOMES OF MOOD DISORDERS
}}

{{PMID Auto
|PMID=19319666
|Title=Genetics of the P2X7 receptor and human disease.
|OA=1
}}

{{PMID Auto
|PMID=19838818
|Title=Identification and characterization of a novel variant of the human P2X(7) receptor resulting in gain of function.
|OA=1
}}

{{PMID Auto
|PMID=21335057
|Title=P2RX7 polymorphisms Gln460Arg and His155Tyr are not associated with major depressive disorder or remission after SSRI or ECT.
}}

{{PMID Auto
|PMID=21438144
|Title=P2RX7 gene is associated consistently with mood disorders and predicts clinical outcome in three clinical cohorts.
}}

{{PMID Auto
|PMID=21906809
|Title=Gain-of-function of P2X7 receptor gene variants in multiple sclerosis.
}}

{{GET Evidence
|gene=P2RX7
|aa_change=Tyr155His
|aa_change_short=Y155H
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs208294
|overall_frequency_n=6453
|overall_frequency_d=10758
|overall_frequency=0.599833
|n_genomes=45
|n_genomes_annotated=0
|n_haplomes=57
|n_articles=0
|n_articles_annotated=0
|nblosum100=-1
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=22661222
|Title=P2X7 receptor activation mediates organic cation uptake into human myeloid leukaemic KG-1 cells.
|OA=1
}}

{{PMID Auto
|PMID=22776862
|Title=Association of P2X7 receptor polymorphisms with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}