{{Rsnum
|rsid=2083637
|Chromosome=8
|position=20007664
|Orientation=minus
|GMAF=0.2365
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 11.5 | 31.9 | 56.6
| HCB | 2.9 | 30.7 | 66.4
| JPT | 7.1 | 25.9 | 67.0
| YRI | 4.1 | 33.6 | 62.3
| ASW | 3.5 | 28.1 | 68.4
| CHB | 2.9 | 30.7 | 66.4
| CHD | 5.5 | 32.1 | 62.4
| GIH | 2.0 | 31.7 | 66.3
| LWK | 4.6 | 30.3 | 65.1
| MEX | 6.9 | 34.5 | 58.6
| MKK | 5.8 | 43.6 | 50.6
| TSI | 7.9 | 37.6 | 54.5
| HapMapRevision=28
}}
[http://www.genomeweb.com/issues/news/151152-1.html news] three SNPs that appear to have different effects in men and women [[rs3846662]] [[rs2304130]] [[rs2083637]]

{{PMID Auto GWAS
|PMID=19060911
|Trait=HDL cholesterol
|Title=Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
|RiskAllele=G
|Pval=6E-18
|OR=0.11
|ORtxt=[NR] SD increase
|OA=1
}}
{{PMID Auto GWAS
|PMID=18454146
|Trait=Waist circumference and related phenotypes
|Title=Common genetic variation near MC4R is associated with waist circumference and insulin resistance
|RiskAllele=
|Pval=0.0000050000000000000004
|OR=NR
|ORtxt=NR
}}

{{PharmGKB
|RSID=rs2083637
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19060911; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (Initial Sample Size: 21,412 individuals; Replication Sample Size: NR); (Region: 8p21.3; Reported Gene(s): LPL; Risk Allele: rs2083637-G); (p-value= 0.000000000000000006).This variant is associated with HDL cholesterol.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740211
}}

{{omim
|desc=LIPOPROTEIN LIPASE; LPL
|id=609708
|rsnum=2083637
}}

{{PMID Auto GWAS
|PMID=20694148
|Trait=None
|Title=A genome-wide association study of the metabolic syndrome in Indian Asian men
|RiskAllele=G
|Pval=2E-10
|OR=0.04
|ORtxt=[0.02-0.05] mmol/l increase
|OA=1
}}

{{PMID Auto
|PMID=19041386
|Title=Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
|OA=1
}}

{{PMID Auto
|PMID=19951432
|Title=Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
|OA=1
}}

{{PMID Auto
|PMID=20160193
|Title=Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.
|OA=1
}}

{{PMID Auto
|PMID=20502693
|Title=Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.
|OA=1
}}

{{PMID Auto
|PMID=21304891
|Title=A study of CNVs as trait-associated polymorphisms and as expression quantitative trait loci.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2083637
|overall_frequency_n=25
|overall_frequency_d=128
|overall_frequency=0.195312
|n_genomes=18
|n_genomes_annotated=0
|n_haplomes=20
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=25156894
|Title=Lipoprotein lipase variants interact with polyunsaturated fatty acids for obesity traits in women: Replication in two populations
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}