{{Rsnum
|rsid=2088885
|Gene=TNIK
|Chromosome=3
|position=171253502
|Orientation=plus
|GMAF=0.4982
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=TNIK
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 24.8 | 57.5 | 17.7
| HCB | 11.7 | 40.1 | 48.2
| JPT | 8.8 | 54.9 | 36.3
| YRI | 48.6 | 43.2 | 8.2
| ASW | 31.6 | 59.6 | 8.8
| CHB | 11.7 | 40.1 | 48.2
| CHD | 16.7 | 44.4 | 38.9
| GIH | 22.8 | 48.5 | 28.7
| LWK | 34.5 | 56.4 | 9.1
| MEX | 17.5 | 56.1 | 26.3
| MKK | 24.4 | 50.0 | 25.6
| TSI | 27.5 | 48.0 | 24.5
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19023125
|Trait=Brain imaging in schizophrenia (interaction)
|Title=A Genome-Wide Association Study of Schizophrenia Using Brain Activation as a Quantitative Phenotype
|RiskAllele=
|Pval=0.000006
|OR=NR
|ORtxt=NR
|OA=1
}}

{{PMID|19023125|OA=1
}} less than 10^-6 p-value interaction with quantitative trait (mean oxygen level-dependent signal in the DLPFC while performing a working memory task [SIRP]) measured (among 64 subjects with schizophrenia and 74 matched controls) - [[TNIK]] related to HPA function and enviromental stress response, in the adult it mediates stress related responses and affects LTP in concert with [[RAPT2]]

{{PharmGKB
|RSID=rs2088885
|Name_s=
|Gene_s=TNIK
|Feature=
|Evidence=PubMed ID:19023125; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: A Genome-Wide Association Study of Schizophrenia Using Brain Activation as a Quantitative Phenotype. (Initial Sample Size: 64 cases, 74 cases; Replication Sample Size: NR); (Region: 3q26.2; Reported Gene(s): TNIK; Risk Allele: rs2088885-?); (p-value= 0.000006).This variant is associated with Brain imaging in schizophrenia (interaction).
|Drugs=
|Drug Classes=
|Diseases=Schizophrenia
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740330
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2088885
|overall_frequency_n=73
|overall_frequency_d=128
|overall_frequency=0.570312
|n_genomes=47
|n_genomes_annotated=0
|n_haplomes=61
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}