{{Rsnum
|rsid=2115819
|Gene=ALOX5
|Chromosome=10
|position=45901089
|Orientation=minus
|GMAF=0.4963
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 12.6 | 49.5 | 37.8
| HCB | 48.9 | 48.9 | 2.2
| JPT | 68.9 | 26.7 | 4.4
| YRI | 4.1 | 33.3 | 62.6
| ASW | 5.6 | 44.4 | 50.0
| CHB | 48.9 | 48.9 | 2.2
| CHD | 0.0 | 0.0 | 0.0
| GIH | 14.9 | 58.4 | 26.7
| LWK | 5.5 | 39.1 | 55.5
| MEX | 28.1 | 50.9 | 21.1
| MKK | 11.0 | 53.5 | 35.5
| TSI | 19.6 | 52.0 | 28.4
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs2115819
|Name_s=ALOX5 (rs2115819)
|Gene_s=ALOX5
|Feature=Intron
|Evidence=PubMed ID:16293801
|Annotation=Associations were found between genotypes of SNPs in the ALOX5 (rs2115819) and MRP1 (rs119774) genes and changes in FEV(1) (p < 0.05) in asthma patients treated with montelukast.
|Drugs=montelukast
|Drug Classes=
|Diseases=Asthma
|Curation Level=Curated
|PharmGKB Accession ID=PA162652699
}}

{{PMID Auto
|PMID=17909879
|Title=Association studies of ALOX5 and bone mineral density in healthy adults.
|OA=1
}}

{{PMID Auto
|PMID=18366797
|Title=Influence of leukotriene gene polymorphisms on chronic rhinosinusitis.
|OA=1
}}

{{PMID Auto
|PMID=19077707
|Title=Pharmacogenetics of asthma.
|OA=1
}}

{{PMID Auto
|PMID=19130089
|Title=Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis.
|OA=1
}}

{{PMID Auto
|PMID=19214143
|Title=5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci.
|OA=1
}}

{{PMID Auto
|PMID=19446447
|Title=Functional variants of the human 5-lipoxygenase gene and their genetic diagnosis.
}}

{{PMID Auto
|PMID=19665766
|Title=Genetics and pharmacogenetics of the leukotriene pathway.
|OA=1
}}

{{PMID Auto
|PMID=20592751
|Title=Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.
|OA=1
}}

{{PMID Auto
|PMID=20592916
|Title=Pharmacogenomic approaches to asthma treatment.
|OA=1
}}

{{PMID Auto
|PMID=21385196
|Title=Influence of leukotriene pathway polymorphisms on clinical responses to montelukast in Japanese patients with asthma.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2115819
|overall_frequency_n=55
|overall_frequency_d=128
|overall_frequency=0.429688
|n_genomes=37
|n_genomes_annotated=0
|n_haplomes=51
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23448388
|Title=ALOX5 is associated with tuberculosis in a subset of the pediatric population of North China.
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}