{{Rsnum
|rsid=2138852
|Chromosome=17
|position=29376331
|Orientation=minus
|GMAF=0.2654
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 32.7 | 46.0 | 21.2
| HCB | 92.7 | 7.3 | 0.0
| JPT | 89.4 | 10.6 | 0.0
| YRI | 91.2 | 8.8 | 0.0
| ASW | 61.4 | 36.8 | 1.8
| CHB | 92.7 | 7.3 | 0.0
| CHD | 94.5 | 5.5 | 0.0
| GIH | 37.6 | 51.5 | 10.9
| LWK | 73.6 | 25.5 | 0.9
| MEX | 33.3 | 54.4 | 12.3
| MKK | 66.7 | 32.1 | 1.3
| TSI | 28.4 | 51.0 | 20.6
| HapMapRevision=28
}}{{PMID|19110211|OA=1
}} [[rs7961894]], [[rs12485738]] and [[rs2138852]] together accounted for 4%-5% of the variance in mean platelet volume, which is increased in myocardial and cerebral infarction and is an independent and strong predictor for postevent morbidity and mortality

{{omim
|desc=MEAN PLATELET VOLUME QUANTITATIVE TRAIT LOCUS 3; MPVQTL3
|id=612575
|rsnum=2138852
}}
{{PMID Auto GWAS
|PMID=19820697
|Trait=MPV
|Title=A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
|RiskAllele=T
|Pval=1E-22
|OR=0.02
|ORtxt=[0.012-0.020] fl increase
|OA=1
}}

{{PharmGKB
|RSID=rs2138852
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19110211
|Annotation=In replicated GWAS (three replication groups) of German and UK populations, this SNP was found to be strongly associated with Mean Platelet Volume. Combined N = 10,048; p= 7.19 x 10 ( -28).
|Drugs=
|Drug Classes=
|Diseases=Cerebral Infarction; Infarction; Myocardial Infarction
|Curation Level=Curated
|PharmGKB Accession ID=PA164920505
}}

{{PharmGKB
|RSID=rs2138852
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19110211; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: A genome-wide association study identifies three loci associated with mean platelet volume. (Initial Sample Size: 1,606 individuals; Replication Sample Size: 8,617 individuals); (Region: 17q11.2; Reported Gene(s): TAOK1; Risk Allele: rs2138852-C); (p-value= 7E-28).This variant is associated with Mean platelet volume.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740099
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2138852
|overall_frequency_n=90
|overall_frequency_d=128
|overall_frequency=0.703125
|n_genomes=45
|n_genomes_annotated=0
|n_haplomes=73
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}