{{Rsnum
|rsid=2144300
|Gene=GALNT2
|Chromosome=1
|position=230159169
|Orientation=plus
|GMAF=0.3558
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=GALNT2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 17.1 | 52.3 | 30.6
| HCB | 58.5 | 36.3 | 5.2
| JPT | 67.0 | 29.5 | 3.6
| YRI | 95.9 | 4.1 | 0.0
| ASW | 68.4 | 28.1 | 3.5
| CHB | 58.5 | 36.3 | 5.2
| CHD | 0.0 | 0.0 | 0.0
| GIH | 41.6 | 44.6 | 13.9
| LWK | 86.2 | 12.8 | 0.9
| MEX | 26.8 | 48.2 | 25.0
| MKK | 81.8 | 14.3 | 3.9
| TSI | 14.1 | 48.5 | 37.4
| HapMapRevision=28
}}

{{GWAS Summary
|SNP=rs2144300
|PubMedID=18193043
|Condition=HDL cholesterol
|Gene=GALNT2
|Risk Allele=T
|pValue=3.00E-014
|OR=1.11
|95CI=NR) mg/dl highe
}}

{{ neighbor
| rsid = 4846914
| distance = 775
}}

{{PharmGKB
|RSID=rs2144300
|Name_s=
|Gene_s=GALNT2
|Feature=
|Evidence=PubMed ID:18193043; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Newly identified loci that influence lipid concentrations and risk of coronary artery disease (Initial Sample Size: 8,656 individuals; Replication Sample Size: 11,399 individuals; Risk Allele: rs2144300-T). This variant is associated with HDL cholesterol levels.
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases; Coronary Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356710
}}

{{PMID Auto
|PMID=21933382
|Title=Association of the GALNT2 gene polymorphisms and several environmental factors with serum lipid levels in the Mulao and Han populations
|OA=1
}}

{{PMID Auto
|PMID=18852197
|Title=Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
|OA=1
}}

{{PMID Auto
|PMID=19041386
|Title=Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
|OA=1
}}

{{PMID Auto
|PMID=19060911
|Title=Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
|OA=1
}}

{{PMID Auto
|PMID=19185284
|Title=Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.
|OA=1
}}

{{PMID Auto
|PMID=19435741
|Title=Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.
|OA=1
}}

{{PMID Auto
|PMID=19822575
|Title=Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing.
|OA=1
}}

{{PMID Auto
|PMID=21347282
|Title=Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2144300
|overall_frequency_n=38
|overall_frequency_d=128
|overall_frequency=0.296875
|n_genomes=27
|n_genomes_annotated=0
|n_haplomes=36
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23620142
  |Trait=Circulating myeloperoxidase levels (serum)
  |Title=Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
  |RiskAllele=C
  |Pval=3E-6
  |OR=.05
  |ORtxt=[0.030-0.070] unit decrease
  }}

{{PMID Auto
|PMID=23832694
|Title=Common genetic variants associated with lipid profiles in a Chinese pediatric population.
}}

{{PMID Auto
|PMID=24116192
|Title=Atenolol induced HDL-C change in the pharmacogenomic evaluation of antihypertensive responses (PEAR) study
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}