{{Rsnum
|rsid=2144908
|Gene=HNF4A
|Chromosome=20
|position=44357077
|Orientation=plus
|GMAF=0.2493
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=HNF4A
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 2.7 | 27.4 | 69.9
| HCB | 19.7 | 51.8 | 28.5
| JPT | 13.3 | 55.8 | 31.0
| YRI | 0.0 | 15.6 | 84.4
| ASW | 0.0 | 31.6 | 68.4
| CHB | 19.7 | 51.8 | 28.5
| CHD | 24.8 | 48.6 | 26.6
| GIH | 10.9 | 35.6 | 53.5
| LWK | 0.0 | 12.7 | 87.3
| MEX | 19.3 | 57.9 | 22.8
| MKK | 1.3 | 16.0 | 82.7
| TSI | 0.0 | 39.2 | 60.8
| HapMapRevision=28
}}Affects type-2 [[diabetes]]

{{PMID|15047633}} {{PMID|15504983}} {{PMID|15735892}} {{PMID|16522129}} {{PMID|16522130}} {{PMID|16523192}} {{PMID|16523193}} {{PMID|16523194}} {{PMID|16752173}}

[[popular in pubmed]]

{{PMID Auto
|PMID=21544032
|Title=Genetic and clinical risk factors of new-onset diabetes after transplantation in Hispanic kidney transplant recipients
}}

{{PMID Auto
|PMID=21633728
|Title=Hepatocyte nuclear factor 4 alpha P2 promoter variants associate with insulin resistance
}}

{{PMID Auto
|PMID=21983932
|Title=Association of Hepatocyte Nuclear Factor 4 Alpha Polymorphisms with Type 2 Diabetes With or Without Metabolic Syndrome in Malaysia
}}

{{PMID|16186411|OA=1
}} Variants in hepatocyte nuclear factor 4alpha are modestly associated with type 2 diabetes in Pima Indians.

{{PMID|16838170}} Single nucleotide polymorphisms of the HNF4alpha gene are associated with the conversion to type 2 diabetes mellitus: the STOP-NIDDM trial.

{{PMID|17805472}} Association of genetic variations near P2 promoter of the hepatocyte nuclear factor-4alpha gene and insulin secretion index in Thais.

{{PMID|17827402}} Studies in 3,523 Norwegians and meta-analysis in 11,571 subjects indicate that variants in the hepatocyte nuclear factor 4 alpha (HNF4A) P2 region are associated with type 2 diabetes in Scandinavians.

{{PMID|17894829}} Gene-gene interactions between HNF4A and KCNJ11 in predicting Type 2 diabetes in women.

{{PMID|18162503}} Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans.

{{PMID|18332101}} Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes.

{{PMID|18340007|OA=1
}} Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia.

{{PMID|18498634|OA=1
}} The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.

{{PMID|18654034}} A common P2 promoter polymorphism of the hepatocyte nuclear factor-4alpha gene is associated with insulin secretion in non-obese Japanese with type 2 diabetes.

{{PMID|18728231|OA=1
}} Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies.

{{PMID|19915572|OA=1
}} Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.

{{PMID|20079163}} Effect of genetic variants in KCNJ11, ABCC8, PPARG and HNF4A loci on the susceptibility of type 2 diabetes in Chinese Han population.

{{PMID|20361036|OA=1
}} Gene-gene interactions lead to higher risk for development of type 2 diabetes in an Ashkenazi Jewish population.

{{PMID|21062274}} Association of novel variants in the hepatocyte nuclear factor 4A gene with maturity onset diabetes of the young and early onset type 2 diabetes.

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}