{{Rsnum
|rsid=2153157
|Gene=SYCP2L
|Chromosome=6
|position=10897255
|Orientation=minus
|GMAF=0.3985
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=SYCP2L
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 23.0 | 55.8 | 21.2
| HCB | 13.1 | 43.8 | 43.1
| JPT | 5.3 | 42.5 | 52.2
| YRI | 5.4 | 36.7 | 57.8
| ASW | 7.1 | 48.2 | 44.6
| CHB | 13.1 | 43.8 | 43.1
| CHD | 9.2 | 45.0 | 45.9
| GIH | 44.6 | 42.6 | 12.9
| LWK | 3.6 | 29.1 | 67.3
| MEX | 39.7 | 51.7 | 8.6
| MKK | 5.8 | 38.5 | 55.8
| TSI | 15.7 | 55.9 | 28.4
| HapMapRevision=28
}}[http://blog.23andme.com/2009/05/18/snpwatch-researchers-link-common-genetic-variations-to-those-changes-a-womans-body-goes-through/ 23andMe blog] [[rs2153157]](A) 	[[Menopause]] about 15 weeks later

{{PMID Auto GWAS
|PMID=19448621
|Trait=Menarche and menopause (age at onset)
|Title=Genome-wide association studies identify loci associated with age at menarche and age at natural menopause
|RiskAllele=T
|Pval=5E-8
|OR=0.29
|ORtxt=[0.19-0.39] years older
|OA=1
}}

{{omim
|desc=MENOPAUSE, NATURAL, AGE AT, QUANTITATIVE TRAIT LOCUS 1; MENOQ1
|id=300488
|rsnum=2153157
}}

{{PMID Auto GWAS
|PMID=22267201
|Trait=None
|Title=Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
|RiskAllele=A
|Pval=8E-12
|OR=0.1650
|ORtxt=None
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2153157
|overall_frequency_n=85
|overall_frequency_d=120
|overall_frequency=0.708333
|n_genomes=45
|n_genomes_annotated=0
|n_haplomes=72
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23508249
|Title=Replication of genetic loci for ages at menarche and menopause in the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) study
}}

{{PMID Auto
|PMID=23592221
|Title=Shared genetic factors for age at natural menopause in Iranian and European women
}}

{{PMID Auto
|PMID=23307926
|Title=A genome-wide association study of early menopause and the combined impact of identified variants.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}