{{Rsnum
|rsid=2156552
|Chromosome=18
|position=49655298
|Orientation=minus
|GMAF=0.129
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 64.6 | 32.7 | 2.7
| HCB | 64.2 | 33.6 | 2.2
| JPT | 75.2 | 22.1 | 2.7
| YRI | 98.0 | 2.0 | 0.0
| ASW | 89.5 | 7.0 | 3.5
| CHB | 64.2 | 33.6 | 2.2
| CHD | 66.1 | 31.2 | 2.8
| GIH | 80.2 | 18.8 | 1.0
| LWK | 96.4 | 3.6 | 0.0
| MEX | 93.1 | 6.9 | 0.0
| MKK | 96.2 | 3.2 | 0.6
| TSI | 74.5 | 22.5 | 2.9
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=18193044
|Trait=HDL cholesterol
|Title=Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
|RiskAllele=A
|Pval=1.9999999999999999E-7
|OR=0.07
|ORtxt=[0.05-0.09]% SD lower
|OA=1
}}
{{PMID Auto GWAS
|PMID=18193043
|Trait=HDL cholesterol
|Title=Newly identified loci that influence lipid concentrations and risk of coronary artery disease
|RiskAllele=T
|Pval=6.0000000000000003E-12
|OR=1.20
|ORtxt=[NR] mg/dl higher
}}

{{PMID Auto GWAS
|PMID=20864672
|Trait=None
|Title=Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease
|RiskAllele=T
|Pval=2E-12
|OR=0.03
|ORtxt=[0.02-0.04] unit increase
|OA=1
}}

{{PMID Auto
|PMID=18852197
|Title=Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
|OA=1
}}

{{PMID Auto
|PMID=19041386
|Title=Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
|OA=1
}}

{{PMID Auto
|PMID=19060910
|Title=Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
|OA=1
}}

{{PMID Auto
|PMID=19148283
|Title=Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=19185284
|Title=Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.
|OA=1
}}

{{PMID Auto
|PMID=19197348
|Title=Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
|OA=1
}}

{{PMID Auto
|PMID=19287092
|Title=Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans.
|OA=1
}}

{{PMID Auto
|PMID=19435741
|Title=Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.
|OA=1
}}

{{PMID Auto
|PMID=20370913
|Title=Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2156552
|overall_frequency_n=114
|overall_frequency_d=128
|overall_frequency=0.890625
|n_genomes=55
|n_genomes_annotated=0
|n_haplomes=99
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}