{{Rsnum
|rsid=216013
|Gene=CACNA1C
|Chromosome=12
|position=2620466
|Orientation=plus
|GMAF=0.2314
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CACNA1C
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 72.6 | 25.7 | 1.8
| HCB | 54.4 | 38.2 | 7.4
| JPT | 34.5 | 47.8 | 17.7
| YRI | 57.8 | 37.4 | 4.8
| ASW | 66.7 | 31.6 | 1.8
| CHB | 54.4 | 38.2 | 7.4
| CHD | 50.5 | 40.4 | 9.2
| GIH | 57.4 | 40.6 | 2.0
| LWK | 45.5 | 42.7 | 11.8
| MEX | 69.0 | 27.6 | 3.4
| MKK | 45.8 | 43.9 | 10.3
| TSI | 58.8 | 37.3 | 3.9
| HapMapRevision=28
}}influences [[warfarin]] dose

{{GWAS Summary
|SNP=rs216013
|PubMedID=18535201
|Condition=Warfarin maintenance dose
|Gene=CACNA1C
|Risk Allele=
|pValue=9.00E-007
|OR=NA
|95CI=
|OA=1
}}

{{PharmGKB
|RSID=rs216013
|Name_s=
|Gene_s=CACNA1C
|Feature=
|Evidence=PubMed ID:18535201
|Annotation=This intronic variant in the membrane calcium-channel gene CACNA1C was correlated with warfarin dose (p = 9.2 &#215; 10&#8722;5) in the index population (n = 181) from a GWAS study of white patients undergoing anticoagulation therapy. Combined analysis of the index and replication populations (n = 374) yielded a p value of 8.6 &#215; 10&#8722;7. &quot;However, this variant did not reach established significance threshold independently in the replication population (P = .002), nor did it achieve significance after multiple testing correction in multivariate modeling (uncorrected P = .003)&quot;.
|Drugs=warfarin
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165110432
}}

{{PharmGKB
|RSID=rs216013
|Name_s=
|Gene_s=CACNA1C
|Feature=
|Evidence=PubMed ID:18535201; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose (Initial Sample Size: 181 individuals; Replication Sample Size: 374 individuals). This variant is associated with Warfarin maintenance dose.
|Drugs=warfarin
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356395
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs216013
|overall_frequency_n=30
|overall_frequency_d=128
|overall_frequency=0.234375
|n_genomes=22
|n_genomes_annotated=0
|n_haplomes=24
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}