{{Rsnum
|rsid=216321
|Gene=VWF
|Chromosome=12
|position=6034818
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.1028
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 80.4 | 18.8 | 0.9
| HCB | 62.8 | 34.3 | 2.9
| JPT | 62.8 | 31.9 | 5.3
| YRI | 95.2 | 4.8 | 0.0
| ASW | 93.0 | 7.0 | 0.0
| CHB | 62.8 | 34.3 | 2.9
| CHD | 67.0 | 29.4 | 3.7
| GIH | 82.2 | 16.8 | 1.0
| LWK | 95.5 | 4.5 | 0.0
| MEX | 81.0 | 17.2 | 1.7
| MKK | 91.7 | 8.3 | 0.0
| TSI | 87.3 | 12.7 | 0.0
| HapMapRevision=28
}}{{Venter SNP
|rsid=216321
|allele=C
|frequency=0.908
|uid=1103649355682
|type=homozygous_SNP
|hugo=VWF
|ensembl gene=ENSG00000110799
|ensembl transcript=ENST00000261405
|sift=TOLERATED
|disease=Defects in VWF are associated with various forms of von Willebrand disease (VWD) (MIM:193400, 277480). VWD is characterized by frequent bleeding (gingival, minor skin quantitative lacerations, menorrhagia, etc.). Type I VWD is associated with a deficiency of VWF; type II by normal to decreased plasma level of VWF; type III by a virtual absence of VWF. There are subtypes (A to H) of type II VWD; for example: type IIA is characterized by the absence of VWF high molecular weight multimers in plasma.
}}

{{PMID Auto
|PMID=18598365
|Title=Analytical approaches to detect maternal/fetal genotype incompatibilities that increase risk of pre-eclampsia.
|OA=1
}}

{{PMID Auto
|PMID=22568520
|Title=von Willebrand factor plasma levels, genetic variations and coronary heart disease in an older population.
}}

{{GET Evidence
|gene=VWF
|aa_change=Gln852Arg
|aa_change_short=Q852R
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs216321
|overall_frequency_n=9938
|overall_frequency_d=10758
|overall_frequency=0.923778
|n_genomes=56
|n_genomes_annotated=0
|n_haplomes=104
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=2
|qualitycomment_in_silico=Y
|gene_in_genetests=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=0
|autoscore=3
|n_web_uneval=6
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}