{{Rsnum
|rsid=2165870
|Chromosome=1
|position=239622120
|Orientation=plus
|GMAF=0.2397
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=CHRM3
|Gene_s=CHRM3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 10.8 | 36.9 | 52.3
| HCB | 4.4 | 31.1 | 64.4
| JPT | 6.8 | 45.5 | 47.7
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 4.4 | 31.1 | 64.4
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs2165870]] is a SNP in or near the promoter region of the muscarinic acetylcholine receptor 3 subtype [[CHRM3]] gene on ch 1.

A GWAS study of 300+ patients exhibiting post-operative nausea found that carriers of [[rs2165870]](A) alleles were at 2.3x higher risk for nausea (CI: 1.36 - 4, p = 0.002).{{PMID|21694509}}

[[rs2355230]] is said to be a perfect proxy (r2 = 1) for [[rs2165870]].{{PMID Auto
|PMID=17903301
|Title=Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study.
|OA=1
}}