{{Rsnum
|rsid=2167270
|Gene=LEP
|Chromosome=7
|position=128241296
|Orientation=plus
|GMAF=0.3503
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=LEP
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 14.2 | 42.5 | 43.4
| HCB | 2.9 | 29.2 | 67.9
| JPT | 1.8 | 32.7 | 65.5
| YRI | 24.0 | 47.3 | 28.8
| ASW | 15.8 | 54.4 | 29.8
| CHB | 2.9 | 29.2 | 67.9
| CHD | 8.3 | 39.4 | 52.3
| GIH | 6.9 | 47.5 | 45.5
| LWK | 20.9 | 55.5 | 23.6
| MEX | 22.4 | 55.2 | 22.4
| MKK | 6.5 | 43.9 | 49.7
| TSI | 8.8 | 47.1 | 44.1
| HapMapRevision=28
}}[[rs2167270]] is a SNP in the leptin [[LEP]] gene.

In a study of ~1,500 [[colon cancer]] patients, the [[rs2167270]](A;A) genotype was underrepresented, leading to an odds ratio of 0.79 (CI: 0.64-0.98).{{PMID|18059035|OA=1
}}

{{PMID Auto
|PMID=20140086
|Title=Genetic Variation at Selected SNPs in the Leptin Gene and Association of Alleles with Markers of Kidney Disease in a Xhosa Population of South Africa
|OA=1
}}

{{PMID Auto
|PMID=21512510
|Title=The Effect of Ponderal Index at Birth on the Relationships Between Common LEP and LEPR Polymorphisms and Adiposity in Adolescents
}}

{{PMID Auto
|PMID=22666399
|Title=Tumor Necrosis Factor-α Induced Protein 8 Polymorphism and Risk of Non-Hodgkin's Lymphoma in a Chinese Population: A Case-Control Study
|OA=1
}}

{{PMID|15197684|OA=1
}} Common variants in the 5' region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study.

{{PMID|19035456|OA=1
}} Adipokine genes and prostate cancer risk.

{{PMID|19204185|OA=1
}} Leptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute Family Heart Study.

{{PMID|19593725|OA=1
}} Association of maternally inherited GNAS alleles with African-American male birth weight.

{{PMID|21385539}} Lack of association between LEP rs2167270 (19 G>A) polymorphism and disease susceptibility and cardiovascular disease in patients with rheumatoid arthritis.

{{PMID Auto
|PMID=23840460
|Title=Lymphotoxin Alpha (LTA) Polymorphism Is Associated with Prognosis of Non-Hodgkin's Lymphoma in a Chinese Population
|OA=1
}}

{{PMID Auto
|PMID=22537818
|Title=Polymorphisms in adiposity-related genes are associated with age at menarche and menopause in breast cancer patients and healthy women.
}}

{{PMID Auto
|PMID=22975643
|Title=Leptin and leptin receptor genetic variants associate with habitual physical activity and the arm body composition response to resistance training.
|OA=1
}}

{{PMID Auto
|PMID=24845032
|Title=Association of LEP A19G polymorphism with cancer risk: a systematic review and pooled analysis
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}