{{Rsnum
|rsid=2180341
|Gene=RNF146
|Chromosome=6
|position=127279485
|Orientation=plus
|GMAF=0.2608
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=RNF146
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 54.9 | 38.9 | 6.2
| HCB | 59.1 | 33.6 | 7.3
| JPT | 62.8 | 34.5 | 2.7
| YRI | 39.5 | 49.7 | 10.9
| ASW | 54.4 | 42.1 | 3.5
| CHB | 59.1 | 33.6 | 7.3
| CHD | 62.4 | 29.4 | 8.3
| GIH | 38.6 | 46.5 | 14.9
| LWK | 54.5 | 34.5 | 10.9
| MEX | 44.8 | 48.3 | 6.9
| MKK | 55.8 | 38.5 | 5.8
| TSI | 52.0 | 43.1 | 4.9
| HapMapRevision=28
}}{{GWAS Summary
|SNP=rs2180341
|PubMedID=18326623
|Condition=Breast cancer
|Gene=ECHDC1,RNF146
|Risk Allele=G
|pValue=3.00E-008
|OR=1.41
|95CI=1.25-1.59
|OA=1
}}

{{PharmGKB
|RSID=rs2180341
|Name_s=
|Gene_s=RNF146
|Feature=
|Evidence=PubMed ID:18326623; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33 (Initial Sample Size: 249 cases, 299 controls (Ashkenazi Jewish, non-BRCA1/2 carriers); Replication Sample Size: 1,193 cases, 1,166 controls (Ashkenazi Jewish, non-BRCA1/2 carriers); Risk Allele: rs2180341-G).
|Drugs=
|Drug Classes=
|Diseases=Breast Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356757
}}

{{PMID Auto
|PMID=21445572
|Title=Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies
}}

{{PMID Auto
|PMID=21791674
|Title=Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium
|OA=1
}}

{{PMID Auto
|PMID=19219042
|Title=Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1.
|OA=1
}}

{{PMID Auto
|PMID=19330030
|Title=A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).
|OA=1
}}

{{PMID Auto
|PMID=19690183
|Title=The 6q22.33 locus and breast cancer susceptibility.
}}

{{PMID Auto
|PMID=20085711
|Title=Leveraging genetic variability across populations for the identification of causal variants.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2180341
|overall_frequency_n=101
|overall_frequency_d=128
|overall_frequency=0.789062
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=87
|n_articles=1
|n_articles_annotated=1
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22269215
|Title=Breast cancer risk assessment with five independent genetic variants and two risk factors in Chinese women
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}