{{Rsnum
|rsid=219780
|Gene=CLDN14
|Chromosome=21
|position=36461009
|Orientation=plus
|GMAF=0.1515
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CLDN14
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 30.5 | 69.5
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 5.3 | 26.3 | 68.4
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
[http://www.nature.com/ng/journal/vaop/ncurrent/abs/ng.404.html nature] Carriers of two C alleles of this SNP in CLDN14 gene have 1.6 times higher risk of [[kidney stones]]. The [[rs219780(C;C)]] genotype is also associated with decreased [[bone mineral density]]. {{PMID|19561606}} Note that the risk genotype is the most common in all populations.

{{PMID Auto GWAS
|PMID=19561606
|Trait=Kidney stones
|Title=Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density
|RiskAllele=C
|Pval=4E-12
|OR=1.25
|ORtxt=[1.17-1.33]
}}

{{omim
|id=605608
|rsnum=219780
}}

{{PMID Auto
|PMID=22396660
|Title=A Genome-Wide Association Study of Nephrolithiasis in the Japanese Population Identifies Novel Susceptible Loci at 5q35.3, 7p14.3, and 13q14.1
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs219780
|overall_frequency_n=2420
|overall_frequency_d=10758
|overall_frequency=0.224949
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=17
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}