{{Rsnum
|rsid=2201841
|Gene=IL23R
|Chromosome=1
|position=67228519
|Orientation=minus
|GMAF=0.3687
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=IL23R
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 10.6 | 38.1 | 51.3
| HCB | 51.1 | 40.9 | 8.0
| JPT | 47.7 | 38.7 | 13.5
| YRI | 2.0 | 24.5 | 73.5
| ASW | 0.0 | 29.8 | 70.2
| CHB | 51.1 | 40.9 | 8.0
| CHD | 50.9 | 44.4 | 4.6
| GIH | 37.0 | 46.0 | 17.0
| LWK | 5.5 | 29.1 | 65.5
| MEX | 8.6 | 36.2 | 55.2
| MKK | 9.6 | 44.2 | 46.2
| TSI | 5.9 | 52.0 | 42.2
| HapMapRevision=28
}}SNP [[rs2201841]], in the [[IL23R]] gene, is associated with increased risk for [[Crohn's disease]] in both Jewish and non-Jewish populations. {{PMID|17068223}}

Another study found that the "A allele" and "AA genotype" were significantly overrepresented in [[Graves' disease]] patients with Graves ophthalmopathy, based on 216 North American patients. The odds ratios reported were 2.04 for the allele (p=1x10<sup>-4</sup>), and for the so-called "AA" genotype (presumably [[rs2201841]](T;T) when correctly oriented to the dbSNP orientation), 2.4 (p=1x10<sup>-4</sup>).{{PMID|18073300|OA=1
}}

[http://blog.23andme.com/2009/01/26/snpwatch-new-psoriasis-snps-found-for-both-europeans-and-asians/ 23andMe blog] [[psoriasis]] 
Europeans
*[[rs2201841]](G) 	1.13x risk

{{GWAS Summary
|SNP=rs2201841
|PubMedID=17804789
|Condition=Crohn's disease
|Gene=IL23R
|Risk Allele=
|pValue=1.00E-008
|OR=1.38
|95CI=1.23-1.53
|OA=1
}}

{{PMID Auto GWAS
|PMID=19169254
|Trait=Psoriasis
|Title=Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
|RiskAllele=G
|Pval=3E-8
|OR=1.13
|ORtxt=None
|OA=1
}}

{{omim
|desc=PSORIASIS SUSCEPTIBILITY 7; PSORS7
|id=605606
|rsnum=2201841
}}
{{PMID Auto
|PMID=19034457
|Title=Lack of association between interleukin 23 receptor gene polymorphisms and rheumatoid arthritis susceptibility
}}

{{PharmGKB
|RSID=rs2201841
|Name_s=
|Gene_s=IL23R
|Feature=
|Evidence=PubMed ID:19169254; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. (Initial Sample Size: 1,359 cases, 1,400 controls; Replication Sample Size: 5,048 cases, 5,041 controls); (Region: 1p31.3; Reported Gene(s): IL23R; Risk Allele: rs2201841-G); (p-value= 0.00000003).This variant is associated with Psoriasis.
|Drugs=
|Drug Classes=
|Diseases=Psoriasis
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740040
}}

{{PMID Auto GWAS
|PMID=20228799
|Trait=Ulcerative colitis
|Title=Genome-wide association identifies multiple ulcerative colitis susceptibility loci
|RiskAllele=A
|Pval=1E-13
|OR=1.27
|ORtxt=[NR]
|OA=1
}}

{{PharmGKB
|RSID=rs2201841
|Name_s=
|Gene_s=IL23R
|Feature=
|Evidence=PubMed ID:17804789; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci (Initial Sample Size: 382 trios; Replication Sample Size: 521 trios, 750 cases, 828 controls). This variant is associated with Crohn's disease. This variant is associated with Crohn's disease.
|Drugs=
|Drug Classes=
|Diseases=Crohn Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356491
}}

{{PMID Auto
|PMID=22089529
|Title=Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis
}}

{{PMID Auto
|PMID=22440928
|Title=Perianal Crohn's Disease: Predictive Factors and Genotype-Phenotype Correlations
|OA=1
}}

{{PMID Auto
|PMID=22411504
|Title=Contribution of higher risk genes and European admixture to Crohn's disease in African Americans.
|OA=1
}}

{{PMID Auto
|PMID=17606463
|Title=Functional variants of interleukin-23 receptor gene confer risk for rheumatoid arthritis but not for systemic sclerosis.
}}

{{PMID Auto
|PMID=17786191
|Title=rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.
|OA=1
}}

{{PMID Auto
|PMID=18338763
|Title=Association of IL23R, TNFRSF1A, and HLA-DRB1*0103 allele variants with inflammatory bowel disease phenotypes in the Finnish population.
}}

{{PMID Auto
|PMID=18383363
|Title=Association of interleukin-23 receptor variants with ankylosing spondylitis.
}}

{{PMID Auto
|PMID=18470928
|Title=IL23R haplotypes provide a large population attributable risk for Crohn's disease.
|OA=1
}}

{{PMID Auto
|PMID=19021011
|Title=Association studies of the IL-23R gene in autoimmune thyroid disease in the Japanese population.
}}

{{PMID Auto
|PMID=19103559
|Title=[Susceptibility genetic variants in Hungarian morbus Crohn and ulcerative colitis patients].
}}

{{PMID Auto
|PMID=19175939
|Title=IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease.
|OA=1
}}

{{PMID Auto
|PMID=19262574
|Title=Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis.
|OA=1
}}

{{PMID Auto
|PMID=19306001
|Title=No association between interleukin 23 receptor gene polymorphisms and systemic lupus erythematosus.
}}

{{PMID Auto
|PMID=19522770
|Title=Variants of the IL23R gene are associated with ankylosing spondylitis but not with Sjogren syndrome in Hungarian population samples.
}}

{{PMID Auto
|PMID=19757086
|Title=Interleukin-23 receptor gene variants in Hungarian systemic lupus erythematosus patients.
}}

{{PMID Auto
|PMID=20066736
|Title=Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn's disease patients.
|OA=1
}}

{{PMID Auto
|PMID=20444268
|Title=Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets.
|OA=1
}}

{{PMID Auto
|PMID=20454450
|Title=Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.
|OA=1
}}

{{PMID Auto
|PMID=20606885
|Title=Genetics of psoriasis and psoriatic arthritis.
|OA=1
}}

{{PMID Auto
|PMID=20978829
|Title=Polymorphisms of the IL23R gene are associated with psoriasis but not with immunoglobulin A nephropathy in a Hungarian population.
}}

{{PMID Auto
|PMID=21253569
|Title=Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations?
|OA=1
}}

{{PMID Auto
|PMID=21304977
|Title=An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
|OA=1
}}

{{PMID Auto
|PMID=23054009
|Title=Marked diversity of IL23R gene haplotype variants in rheumatoid arthritis comparing with Crohn's disease and ankylosing spondylitis
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2201841
|overall_frequency_n=41
|overall_frequency_d=128
|overall_frequency=0.320312
|n_genomes=27
|n_genomes_annotated=0
|n_haplomes=34
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23093364
|Title=Difference of interleukin-23 receptor gene haplotype variants in ulcerative colitis compared to Crohn's disease and psoriasis
}}

{{PMID Auto
|PMID=24415875
|Title=Susceptibility to ulcerative colitis in Hungarian patients determined by gene-gene interactions
|OA=1
}}

{{PMID Auto
|PMID=22706445
|Title=Association of IL23R polymorphisms with psoriasis and psoriatic arthritis: a meta-analysis.
}}

{{PMID Auto
|PMID=23053963
|Title=Associations between interleukin-23 receptor polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis.
}}

{{PMID Auto
|PMID=24957500
|Title=Genetic variation at IL12B, IL23R and IL23A is associated with psoriasis severity, psoriatic arthritis and type 2 diabetes mellitus
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}