{{Rsnum
|rsid=2209972
|Gene=MARK2P9
|Chromosome=10
|position=94179028
|Orientation=plus
|GMAF=0.4233
|Assembly=GRCh37.p2
|GenomeBuild=37.2
|dbSNPBuild=134
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 49.2 | 38.1 | 12.7
| HCB | 8.9 | 31.1 | 60.0
| JPT | 9.1 | 43.2 | 47.7
| YRI | 73.0 | 25.4 | 1.6
| ASW | 0.0 | 0.0 | 0.0
| CHB | 8.9 | 31.1 | 60.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs2209972]], a SNP associated with the insulin-degrading enzyme gene [[IDE]], has been identified as occuring at higher frequency in Chinese female patients with [[polycystic ovary syndrome]] (PCOS). The [[IDE]] gene has been linked to [[type-2 diabetes]], and many patients with PCOS have endocrine abnormalities that suggest a shared etiology with [[type-2 diabetes]].

The risk allele for this SNP is [[rs2209972(C)]], and in this study comparing ~300 patients to an equal number of controls the [[rs2209972(C;C)]] and [[rs2209972(C;T)]] genotypes were associated with higher fasting insulin levels, a higher body mass index (BMI), and (theoretically) insulin resistance (HOMA-IR) than [[rs2209972(T;T)]] carriers. {{PMID|17953957}}

{{PMID Auto
|PMID=24355596
|Title=C allele of the rs2209972 single nucleotide polymorphism of the insulin degrading enzyme gene and Alzheimer's disease in type 2 diabetes, a case control study
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}