{{Rsnum
|rsid=2227311
|Gene=RB1
|Chromosome=13
|position=48412896
|Orientation=minus
|GMAF=0.1019
|Gene_s=LPAR6,RB1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 23.9 | 76.1
| HCB | 0.7 | 16.8 | 82.5
| JPT | 0.0 | 16.8 | 83.2
| YRI | 0.0 | 8.2 | 91.8
| ASW | 0.0 | 10.5 | 89.5
| CHB | 0.7 | 16.8 | 82.5
| CHD | 0.9 | 11.9 | 87.2
| GIH | 1.0 | 21.8 | 77.2
| LWK | 0.0 | 9.1 | 90.9
| MEX | 1.7 | 24.1 | 74.1
| MKK | 0.0 | 4.5 | 95.5
| TSI | 2.0 | 28.4 | 69.6
| HapMapRevision=28
}}This SNP has been linked to another SNP, [[rs4151620]] which has been linked to [[ovarian cancer]] {{PMID|17047088}}.

More specifically: [[rs2227311]](C) alleles were found to be perfectly correlated to [[rs4151620]](G) alleles, and carriers of two [[rs4151620]](G) alleles have a 5X reduced risk of developing ovarian cancer compared to carriers of two [[rs4151620]](C) alleles, in a survey of ~5,000 women from the US, UK, and Denmark. {{PMID|17047088}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}